Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice

Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice

Background: This study aimed to investigate diurnal variations in copper-induced hepatic toxicity and the molecular mechanisms underlying this chronotoxicity. Methods: Male C57BL/6J mice were intraperitoneally injected with copper chloride (CuCl2) at zeitgeber time 2 (ZT2) or 14 (ZT14), twice per we...

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Bibliographic Details
Main Authors: Sarah Tominaga, Hiroki Yoshioka, Satoshi Yokota, Yosuke Tsukiboshi, Masumi Suzui, Makoto Nagai, Hirokazu Hara, Tohru Maeda, Nobuhiko Miura
Format: Article
Language:English
Published: Komiyama Printing Co. Ltd 2023-12-01
Series:Environmental Health and Preventive Medicine
Subjects:
copper
chronotoxicity
hepatotoxicity
Online Access:https://www.jstage.jst.go.jp/article/ehpm/28/0/28_23-00205/_html/-char/en

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