A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant <i>Plantago loeflingii</i> L.
A new glucosyl flavone, 5,7,2′,5′-tetrahydroxyflavone 7-<i>O</i>-β-<span style="font-variant: small-caps;">d</span>-glucopyranoside, named loeflingiin, together with apigenin 6-<i>C</i>-glucoside (isovitexin), coumarins citropten and isompinellin, triter...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Molecules |
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| author | Hawraz Ibrahim M. Amin Kamaran Younis M. Amin Chabaco Armijos Faiq H. S. Hussain Zanko Hassan Jawhar Diego Caprioglio Mariella Mella Giovanni Vidari |
| author_facet | Hawraz Ibrahim M. Amin Kamaran Younis M. Amin Chabaco Armijos Faiq H. S. Hussain Zanko Hassan Jawhar Diego Caprioglio Mariella Mella Giovanni Vidari |
| author_sort | Hawraz Ibrahim M. Amin |
| collection | DOAJ |
| description | A new glucosyl flavone, 5,7,2′,5′-tetrahydroxyflavone 7-<i>O</i>-β-<span style="font-variant: small-caps;">d</span>-glucopyranoside, named loeflingiin, together with apigenin 6-<i>C</i>-glucoside (isovitexin), coumarins citropten and isompinellin, triterpenoids betulin and betulinic acid, and a mixture of phytosterols β-sitosterol, stigmasterol and campesterol were isolated for the first time from the leaves of wild <i>Plantago loeflingii</i> L. (<i>Plantaginaceae</i>) collected in the Iraqi Kurdistan region. The plant is used by local people to treat wounds and as a vulnerary remedy. The structures of isolated compounds were determined by spectroscopic analysis. The activities of isovitexin and loeflingiinon the viability of breast (MCF7), ovarian (BG-1), endometrial (Ishikawa), and mesothelioma (IST-MES1) human cancer cells and two normal cell lines were determined with an MTT assay. Notably, the new 7-<i>O</i>-glucosyl flavone showed effects higher than cisplatin against the Ishikawa and IST-MESI cell lines. The significant biological activities exhibited by all the compounds isolated from <i>P. loeflingii</i> provided scientific evidence to support the use of the plant in the Kurdish traditional medicine. |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-25T00:23:26Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-81fdb1a6d7ee41a383c962fe286a7a5c2024-03-12T16:50:59ZengMDPI AGMolecules1420-30492024-02-01295107910.3390/molecules29051079A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant <i>Plantago loeflingii</i> L.Hawraz Ibrahim M. Amin0Kamaran Younis M. Amin1Chabaco Armijos2Faiq H. S. Hussain3Zanko Hassan Jawhar4Diego Caprioglio5Mariella Mella6Giovanni Vidari7Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil 44001, IraqDepartment of Chemistry, College of Education, Salahaddin University-Erbil, Erbil 44001, IraqDepartamento de Química, Universidad Técnica Particular de Loja, Loja 110107, EcuadorDepartment of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil 44001, IraqDepartment of Science, College of Health Science, Lebanese French University, Erbil 44001, IraqDepartment of Pharmaceutical Sciences, University of Eastern Piedmont, Largo Donegani 2, 28100 Novara, ItalyDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, ItalyDepartment of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil 44001, IraqA new glucosyl flavone, 5,7,2′,5′-tetrahydroxyflavone 7-<i>O</i>-β-<span style="font-variant: small-caps;">d</span>-glucopyranoside, named loeflingiin, together with apigenin 6-<i>C</i>-glucoside (isovitexin), coumarins citropten and isompinellin, triterpenoids betulin and betulinic acid, and a mixture of phytosterols β-sitosterol, stigmasterol and campesterol were isolated for the first time from the leaves of wild <i>Plantago loeflingii</i> L. (<i>Plantaginaceae</i>) collected in the Iraqi Kurdistan region. The plant is used by local people to treat wounds and as a vulnerary remedy. The structures of isolated compounds were determined by spectroscopic analysis. The activities of isovitexin and loeflingiinon the viability of breast (MCF7), ovarian (BG-1), endometrial (Ishikawa), and mesothelioma (IST-MES1) human cancer cells and two normal cell lines were determined with an MTT assay. Notably, the new 7-<i>O</i>-glucosyl flavone showed effects higher than cisplatin against the Ishikawa and IST-MESI cell lines. The significant biological activities exhibited by all the compounds isolated from <i>P. loeflingii</i> provided scientific evidence to support the use of the plant in the Kurdish traditional medicine.https://www.mdpi.com/1420-3049/29/5/10797-<i>O</i>-glucosyl flavone<i>Plantago loeflingii</i> L.<i>Plantaginaceae</i>antiproliferative activityKurdish medicinal plant |
| spellingShingle | Hawraz Ibrahim M. Amin Kamaran Younis M. Amin Chabaco Armijos Faiq H. S. Hussain Zanko Hassan Jawhar Diego Caprioglio Mariella Mella Giovanni Vidari A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant <i>Plantago loeflingii</i> L. Molecules 7-<i>O</i>-glucosyl flavone <i>Plantago loeflingii</i> L. <i>Plantaginaceae</i> antiproliferative activity Kurdish medicinal plant |
| title | A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant <i>Plantago loeflingii</i> L. |
| title_full | A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant <i>Plantago loeflingii</i> L. |
| title_fullStr | A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant <i>Plantago loeflingii</i> L. |
| title_full_unstemmed | A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant <i>Plantago loeflingii</i> L. |
| title_short | A New Glucosyl Flavone with Inhibitory Activity of Cancer Cell Viability and Other Bioactive Constituents from the Traditional Kurdish Plant <i>Plantago loeflingii</i> L. |
| title_sort | new glucosyl flavone with inhibitory activity of cancer cell viability and other bioactive constituents from the traditional kurdish plant i plantago loeflingii i l |
| topic | 7-<i>O</i>-glucosyl flavone <i>Plantago loeflingii</i> L. <i>Plantaginaceae</i> antiproliferative activity Kurdish medicinal plant |
| url | https://www.mdpi.com/1420-3049/29/5/1079 |
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