Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery
<i>Background and Objectives:</i> The aim of this study was to investigate the prognostic value of soluble ST2 (sST2) in predicting postoperative adverse events in patients with impaired left ventricular (LV) function undergoing coronary artery bypass graft (CABG) surgery. <i>Mater...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-09-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1010-660X/55/9/572 |
| _version_ | 1797708461238124544 |
|---|---|
| author | Ahmet Dolapoglu Eyup Avci Tarik Yildirim Hasan Kadi Ahmet Celik |
| author_facet | Ahmet Dolapoglu Eyup Avci Tarik Yildirim Hasan Kadi Ahmet Celik |
| author_sort | Ahmet Dolapoglu |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> The aim of this study was to investigate the prognostic value of soluble ST2 (sST2) in predicting postoperative adverse events in patients with impaired left ventricular (LV) function undergoing coronary artery bypass graft (CABG) surgery. <i>Materials and Methods:</i> This study included 80 consecutive patients with stable coronary artery disease (CAD) and impaired LV function (ejection fraction ≤ 45%) undergoing on-pump coronary artery bypass graft surgery. The patients were divided into the “high” or “low” group according to their ST2 levels (≥35 or <35 ng/mL). <i>Results:</i> Postoperative adverse events were more common in patients with high sST2 levels than in patients with low sST2 levels (100% vs 26%, <i>p</i> < 0.0001). Multivariate analysis showed that sST2 level was an independent predictor of the presence of postoperative adverse events (OR: 1.117 (95% CI: 1.016−1.228), <i>p</i> = 0.022). The receiver operating characteristic curve (ROC) analysis of sST2 revealed an area under the curve (AUC) of 0.812 (95% CI: 0.710−0.913, <i>p</i> < 0.001) in predicting postoperative adverse events. An sST2 level of 26.50 ng/ml was identified as the optimal cut-off value, with a sensitivity and specificity of 74.1% and 75.3%, respectively. <i>Conclusion:</i> Higher sST2 levels were associated with adverse outcomes after CABG in patients with impaired LV and stable CAD. |
| first_indexed | 2024-03-12T06:23:04Z |
| format | Article |
| id | doaj.art-81fdd99d4ee44daeb9d50a2f2c9ce6cc |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T06:23:04Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-81fdd99d4ee44daeb9d50a2f2c9ce6cc2023-09-03T02:08:38ZengMDPI AGMedicina1010-660X2019-09-0155957210.3390/medicina55090572medicina55090572Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass SurgeryAhmet Dolapoglu0Eyup Avci1Tarik Yildirim2Hasan Kadi3Ahmet Celik4Department of Cardiovascular Surgery, Balikesir University Medical School, 10145 Balikesir, TurkeyDepartment of Cardiology, Balikesir University Medical School, 10145 Balikesir, TurkeyDepartment of Cardiology, Mugla University Medical School, 48000 Mugla, TurkeyDepartment of Cardiology, Balikesir University Medical School, 10145 Balikesir, TurkeyDepartment of Cardiology, Mersin University Medical School, 33000 Mersin, Turkey<i>Background and Objectives:</i> The aim of this study was to investigate the prognostic value of soluble ST2 (sST2) in predicting postoperative adverse events in patients with impaired left ventricular (LV) function undergoing coronary artery bypass graft (CABG) surgery. <i>Materials and Methods:</i> This study included 80 consecutive patients with stable coronary artery disease (CAD) and impaired LV function (ejection fraction ≤ 45%) undergoing on-pump coronary artery bypass graft surgery. The patients were divided into the “high” or “low” group according to their ST2 levels (≥35 or <35 ng/mL). <i>Results:</i> Postoperative adverse events were more common in patients with high sST2 levels than in patients with low sST2 levels (100% vs 26%, <i>p</i> < 0.0001). Multivariate analysis showed that sST2 level was an independent predictor of the presence of postoperative adverse events (OR: 1.117 (95% CI: 1.016−1.228), <i>p</i> = 0.022). The receiver operating characteristic curve (ROC) analysis of sST2 revealed an area under the curve (AUC) of 0.812 (95% CI: 0.710−0.913, <i>p</i> < 0.001) in predicting postoperative adverse events. An sST2 level of 26.50 ng/ml was identified as the optimal cut-off value, with a sensitivity and specificity of 74.1% and 75.3%, respectively. <i>Conclusion:</i> Higher sST2 levels were associated with adverse outcomes after CABG in patients with impaired LV and stable CAD.https://www.mdpi.com/1010-660X/55/9/572soluble ST2coronary artery bypass graft surgerypostoperative adverse events |
| spellingShingle | Ahmet Dolapoglu Eyup Avci Tarik Yildirim Hasan Kadi Ahmet Celik Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery Medicina soluble ST2 coronary artery bypass graft surgery postoperative adverse events |
| title | Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery |
| title_full | Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery |
| title_fullStr | Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery |
| title_full_unstemmed | Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery |
| title_short | Using Soluble ST2 to Predict Adverse Postoperative Outcomes in Patients with Impaired Left Ventricular Function Undergoing Coronary Bypass Surgery |
| title_sort | using soluble st2 to predict adverse postoperative outcomes in patients with impaired left ventricular function undergoing coronary bypass surgery |
| topic | soluble ST2 coronary artery bypass graft surgery postoperative adverse events |
| url | https://www.mdpi.com/1010-660X/55/9/572 |
| work_keys_str_mv | AT ahmetdolapoglu usingsolublest2topredictadversepostoperativeoutcomesinpatientswithimpairedleftventricularfunctionundergoingcoronarybypasssurgery AT eyupavci usingsolublest2topredictadversepostoperativeoutcomesinpatientswithimpairedleftventricularfunctionundergoingcoronarybypasssurgery AT tarikyildirim usingsolublest2topredictadversepostoperativeoutcomesinpatientswithimpairedleftventricularfunctionundergoingcoronarybypasssurgery AT hasankadi usingsolublest2topredictadversepostoperativeoutcomesinpatientswithimpairedleftventricularfunctionundergoingcoronarybypasssurgery AT ahmetcelik usingsolublest2topredictadversepostoperativeoutcomesinpatientswithimpairedleftventricularfunctionundergoingcoronarybypasssurgery |