Glycated ACE2 reduces anti-remodeling effects of renin-angiotensin system inhibition in human diabetic hearts

Glycated ACE2 reduces anti-remodeling effects of renin-angiotensin system inhibition in human diabetic hearts

Abstract Background High glycated-hemoglobin (HbA1c) levels correlated with an elevated risk of adverse cardiovascular outcomes despite renin-angiotensin system (RAS) inhibition in type-2 diabetic (T2DM) patients with reduced ejection fraction. Using the routine biopsies of non-T2DM heart transplant...

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Main Authors: Raffaele Marfella, Nunzia D’Onofrio, Gelsomina Mansueto, Vincenzo Grimaldi, Maria Consiglia Trotta, Celestino Sardu, Ferdinando Carlo Sasso, Lucia Scisciola, Cristiano Amarelli, Salvatore Esposito, Michele D’Amico, Paolo Golino, Marisa De Feo, Giuseppe Signoriello, Pasquale Paolisso, Emanuele Gallinoro, Marc Vanderheyden, Ciro Maiello, Maria Luisa Balestrieri, Emanuele Barbato, Claudio Napoli, Giuseppe Paolisso
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cardiovascular Diabetology
Subjects:
Heart transplantation
Diabetes
HbA1c
Diabetic cardiomyopathy
RAS-inhibition therapy
Online Access:https://doi.org/10.1186/s12933-022-01573-x

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