Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems
Ru-based chemotherapy is emerging as an effective alternative to the well-established Pt-based one, typically associated with high toxicity. In this context, our recent efforts were devoted to the preparation of nucleolipid-based Ru(III) complexes able to form, under physiological conditions, supram...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/15/5775 |
| _version_ | 1797586320104620032 |
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| author | Claudia Riccardi Chiara Platella Domenica Musumeci Daniela Montesarchio |
| author_facet | Claudia Riccardi Chiara Platella Domenica Musumeci Daniela Montesarchio |
| author_sort | Claudia Riccardi |
| collection | DOAJ |
| description | Ru-based chemotherapy is emerging as an effective alternative to the well-established Pt-based one, typically associated with high toxicity. In this context, our recent efforts were devoted to the preparation of nucleolipid-based Ru(III) complexes able to form, under physiological conditions, supramolecular aggregates which can efficiently prevent metal deactivation and convey Ru(III) inside the cells where it exerts its activity. Within an interdisciplinary program for the development of multifunctional nanoparticles for theranostic applications, we here report the design, synthesis, and characterization of a novel functionalized Ru(III) salt, carrying a lipoic acid moiety in the nucleolipid-based scaffold to allow its incorporation onto metal-based nanoparticles. |
| first_indexed | 2024-03-11T00:20:38Z |
| format | Article |
| id | doaj.art-8205f699b01c4250befdb78eb3540f3a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:20:38Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8205f699b01c4250befdb78eb3540f3a2023-11-18T23:18:43ZengMDPI AGMolecules1420-30492023-07-012815577510.3390/molecules28155775Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different NanosystemsClaudia Riccardi0Chiara Platella1Domenica Musumeci2Daniela Montesarchio3Department of Chemical Sciences, University of Napoli Federico II, 80126 Napoli, ItalyDepartment of Chemical Sciences, University of Napoli Federico II, 80126 Napoli, ItalyDepartment of Chemical Sciences, University of Napoli Federico II, 80126 Napoli, ItalyDepartment of Chemical Sciences, University of Napoli Federico II, 80126 Napoli, ItalyRu-based chemotherapy is emerging as an effective alternative to the well-established Pt-based one, typically associated with high toxicity. In this context, our recent efforts were devoted to the preparation of nucleolipid-based Ru(III) complexes able to form, under physiological conditions, supramolecular aggregates which can efficiently prevent metal deactivation and convey Ru(III) inside the cells where it exerts its activity. Within an interdisciplinary program for the development of multifunctional nanoparticles for theranostic applications, we here report the design, synthesis, and characterization of a novel functionalized Ru(III) salt, carrying a lipoic acid moiety in the nucleolipid-based scaffold to allow its incorporation onto metal-based nanoparticles.https://www.mdpi.com/1420-3049/28/15/5775Ru(III) complexesamphiphilic compoundsnucleolipidslipoic acidchemical synthesishalf-life time |
| spellingShingle | Claudia Riccardi Chiara Platella Domenica Musumeci Daniela Montesarchio Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems Molecules Ru(III) complexes amphiphilic compounds nucleolipids lipoic acid chemical synthesis half-life time |
| title | Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems |
| title_full | Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems |
| title_fullStr | Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems |
| title_full_unstemmed | Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems |
| title_short | Design, Synthesis, and Characterization of an Amphiphilic Lipoic Acid-Based Ru(III) Complex as a Versatile Tool for the Functionalization of Different Nanosystems |
| title_sort | design synthesis and characterization of an amphiphilic lipoic acid based ru iii complex as a versatile tool for the functionalization of different nanosystems |
| topic | Ru(III) complexes amphiphilic compounds nucleolipids lipoic acid chemical synthesis half-life time |
| url | https://www.mdpi.com/1420-3049/28/15/5775 |
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