Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)
Eighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v. on day 1, followed by bleomycin 30mg/day by infusion, days 1-3, and cis-platinum 120mg/m2 on day 4. 9/18 pts. Achieved complete remission an...
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| Format: | Article |
| Language: | English |
| Published: |
Instituto Nacional de Câncer (INCA)
2023-08-01
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| Series: | Revista Brasileira de Cancerologia |
| Subjects: | |
| Online Access: | https://rbc.inca.gov.br/index.php/revista/article/view/3218 |
| _version_ | 1827265566491017216 |
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| author | Sergio D. Simon Miguel Srougi |
| author_facet | Sergio D. Simon Miguel Srougi |
| author_sort | Sergio D. Simon |
| collection | DOAJ |
| description |
Eighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v. on day 1, followed by bleomycin 30mg/day by infusion, days 1-3, and cis-platinum 120mg/m2 on day 4. 9/18 pts. Achieved complete remission and have been followed clinically; no recurrences have occurred in this group. The other 9 pts. had residual masses after 3 cycles of chemotherapy; they were taken to surgery and no viable tumor was found on surgical specimens. There were 3 recurrences in this group, always distant from the site of original disease. These patients were successfully treated with salvage chemotherapy and radiotherapy. One of these patients died of hepatic failure unrelated to his seminoma. All the other patients are alive, at a median follow-up of 50 months. This chemotherapy regimen is effective in curing advanced seminoma.
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| first_indexed | 2024-03-07T17:20:11Z |
| format | Article |
| id | doaj.art-820b7465c3894bc3b67c7cd65b5a1483 |
| institution | Directory Open Access Journal |
| issn | 2176-9745 |
| language | English |
| last_indexed | 2025-03-22T04:03:59Z |
| publishDate | 2023-08-01 |
| publisher | Instituto Nacional de Câncer (INCA) |
| record_format | Article |
| series | Revista Brasileira de Cancerologia |
| spelling | doaj.art-820b7465c3894bc3b67c7cd65b5a14832024-04-28T10:01:20ZengInstituto Nacional de Câncer (INCA)Revista Brasileira de Cancerologia2176-97452023-08-0133410.32635/2176-9745.RBC.1987v33n4.3218Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol)Sergio D. Simon 0Miguel Srougi 1Department of Oncology, Hospital Albert Einstein and Hospital Sírio-Libanês. São Paulo (SP), BrasilDepartment of Urology, University of São Paulo. São Paulo (SP), Brasil Eighteen patients with advanced seminoma (stages llc— III) were treated with: cytoxan 600mg/m2, vinblastine 4mg/m2, actinomycin D 1mg/m2, bleomycin 30mg, i.v. on day 1, followed by bleomycin 30mg/day by infusion, days 1-3, and cis-platinum 120mg/m2 on day 4. 9/18 pts. Achieved complete remission and have been followed clinically; no recurrences have occurred in this group. The other 9 pts. had residual masses after 3 cycles of chemotherapy; they were taken to surgery and no viable tumor was found on surgical specimens. There were 3 recurrences in this group, always distant from the site of original disease. These patients were successfully treated with salvage chemotherapy and radiotherapy. One of these patients died of hepatic failure unrelated to his seminoma. All the other patients are alive, at a median follow-up of 50 months. This chemotherapy regimen is effective in curing advanced seminoma. https://rbc.inca.gov.br/index.php/revista/article/view/3218Seminoma ChemotherapyAdvanced Seminoma |
| spellingShingle | Sergio D. Simon Miguel Srougi Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) Revista Brasileira de Cancerologia Seminoma Chemotherapy Advanced Seminoma |
| title | Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
| title_full | Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
| title_fullStr | Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
| title_full_unstemmed | Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
| title_short | Treatment of Advanced Seminoma with Dactinomycin, Cyclophosphamide, Vinblastine, Bleomycin and Cis-Platinum (The Vab-6 Protocol) |
| title_sort | treatment of advanced seminoma with dactinomycin cyclophosphamide vinblastine bleomycin and cis platinum the vab 6 protocol |
| topic | Seminoma Chemotherapy Advanced Seminoma |
| url | https://rbc.inca.gov.br/index.php/revista/article/view/3218 |
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