Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid
This work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/5/3/25 |
| _version_ | 1819212782576336896 |
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| author | Camilo González-Vargas Núria Serrano Cristina Ariño Ricardo Salazar Miquel Esteban José Manuel Díaz-Cruz |
| author_facet | Camilo González-Vargas Núria Serrano Cristina Ariño Ricardo Salazar Miquel Esteban José Manuel Díaz-Cruz |
| author_sort | Camilo González-Vargas |
| collection | DOAJ |
| description | This work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydrochlorothiazide (HCTZ) by differential pulse voltammetry. Both electrochemical characterization and analytical performance indicate that SPCE/EGA is a much better sensor for HCTZ. The detection and quantification limits were at the level of μmol L−1 with a very good linearity in the studied concentration range. In addition, the proposed SPCE/EGA was successfully applied for the determination of HCTZ in an anti-hypertensive drug with high reproducibility and good trueness. |
| first_indexed | 2024-12-23T06:48:26Z |
| format | Article |
| id | doaj.art-820b812e8e0344d3a6517ee9d084ab4c |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-12-23T06:48:26Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-820b812e8e0344d3a6517ee9d084ab4c2022-12-21T17:56:30ZengMDPI AGChemosensors2227-90402017-09-01532510.3390/chemosensors5030025chemosensors5030025Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic AcidCamilo González-Vargas0Núria Serrano1Cristina Ariño2Ricardo Salazar3Miquel Esteban4José Manuel Díaz-Cruz5Laboratorio de Electroquímica del Medio Ambiente, Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile, USACh, Casilla 40, Correo 33, Santiago 71783-5, ChileDepartament d’Enginyeria Química i Química Analítica, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, E-08028 Barcelona, SpainDepartament d’Enginyeria Química i Química Analítica, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, E-08028 Barcelona, SpainLaboratorio de Electroquímica del Medio Ambiente, Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile, USACh, Casilla 40, Correo 33, Santiago 71783-5, ChileDepartament d’Enginyeria Química i Química Analítica, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, E-08028 Barcelona, SpainDepartament d’Enginyeria Química i Química Analítica, Facultat de Química, Universitat de Barcelona, Martí i Franquès 1-11, E-08028 Barcelona, SpainThis work deals with the development of screen-printed carbon electrodes modified with L-glutamic acid via two different approaches: electropolymerization (SPCE/PGA) and aryl diazonium electrochemical grafting (SPCE/EGA). SPCE/PGA and SPCE/EGA were analytically compared in the determination of hydrochlorothiazide (HCTZ) by differential pulse voltammetry. Both electrochemical characterization and analytical performance indicate that SPCE/EGA is a much better sensor for HCTZ. The detection and quantification limits were at the level of μmol L−1 with a very good linearity in the studied concentration range. In addition, the proposed SPCE/EGA was successfully applied for the determination of HCTZ in an anti-hypertensive drug with high reproducibility and good trueness.https://www.mdpi.com/2227-9040/5/3/25glutamic acid-modified screen-printed electrodevoltammetryelectropolymerizationelectrograftinghydrochlorothiazide determination |
| spellingShingle | Camilo González-Vargas Núria Serrano Cristina Ariño Ricardo Salazar Miquel Esteban José Manuel Díaz-Cruz Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid Chemosensors glutamic acid-modified screen-printed electrode voltammetry electropolymerization electrografting hydrochlorothiazide determination |
| title | Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid |
| title_full | Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid |
| title_fullStr | Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid |
| title_full_unstemmed | Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid |
| title_short | Voltammetric Determination of Anti-Hypertensive Drug Hydrochlorothiazide Using Screen-Printed Electrodes Modified with L-Glutamic Acid |
| title_sort | voltammetric determination of anti hypertensive drug hydrochlorothiazide using screen printed electrodes modified with l glutamic acid |
| topic | glutamic acid-modified screen-printed electrode voltammetry electropolymerization electrografting hydrochlorothiazide determination |
| url | https://www.mdpi.com/2227-9040/5/3/25 |
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