Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy
Abstract Androgen deprivation therapy (ADT) is a crucial and effective strategy for prostate cancer, while systemic administration may cause profound side effects on normal tissues. More importantly, the ADT can easily lead to resistance by involving the activation of NF-κB signaling pathway and hig...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-024-02458-9 |
| _version_ | 1797199200329400320 |
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| author | Yiming Guo Jicheng Wu Lefan Chen Lujie Liu Tianxiang Bi Yuanwei Pan Qian-Fang Meng Chaoliang Wang Lang Rao Qi Li |
| author_facet | Yiming Guo Jicheng Wu Lefan Chen Lujie Liu Tianxiang Bi Yuanwei Pan Qian-Fang Meng Chaoliang Wang Lang Rao Qi Li |
| author_sort | Yiming Guo |
| collection | DOAJ |
| description | Abstract Androgen deprivation therapy (ADT) is a crucial and effective strategy for prostate cancer, while systemic administration may cause profound side effects on normal tissues. More importantly, the ADT can easily lead to resistance by involving the activation of NF-κB signaling pathway and high infiltration of M2 macrophages in tumor microenvironment (TME). Herein, we developed a biomimetic nanotherapeutic platform by deriving cell membrane nanovesicles from cancer cells and probiotics to yield the hybrid cellular nanovesicles (hNVs), loading flutamide (Flu) into the resulting hNVs, and finally modifying the hNVs@Flu with Epigallocatechin-3-gallate (EGCG). In this nanotherapeutic platform, the hNVs significantly improved the accumulation of hNVs@Flu-EGCG in tumor sites and reprogramed immunosuppressive M2 macrophages into antitumorigenic M1 macrophages, the Flu acted on androgen receptors and inhibited tumor proliferation, and the EGCG promoted apoptosis of prostate cancer cells by inhibiting the NF-κB pathway, thus synergistically stimulating the antitumor immunity and reducing the side effects and resistance of ADT. In a prostate cancer mouse model, the hNVs@Flu-EGCG significantly extended the lifespan of mice with tumors and led to an 81.78% reduction in tumor growth compared with the untreated group. Overall, the hNVs@Flu-EGCG are safe, modifiable, and effective, thus offering a promising platform for effective therapeutics of prostate cancer. Graphical Abstract |
| first_indexed | 2024-04-24T07:11:58Z |
| format | Article |
| id | doaj.art-820b927c466842f88eacc4d160f6b07f |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-24T07:11:58Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-820b927c466842f88eacc4d160f6b07f2024-04-21T11:29:05ZengBMCJournal of Nanobiotechnology1477-31552024-04-0122111610.1186/s12951-024-02458-9Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapyYiming Guo0Jicheng Wu1Lefan Chen2Lujie Liu3Tianxiang Bi4Yuanwei Pan5Qian-Fang Meng6Chaoliang Wang7Lang Rao8Qi Li9Department of Urology, The First Affiliated Hospital of Zhengzhou UniversityInstitute of Biomedical Health Technology and Engineering, Shenzhen Bay LaboratoryDepartment of Urology, The First Affiliated Hospital of Zhengzhou UniversityInstitute of Biomedical Health Technology and Engineering, Shenzhen Bay LaboratoryDepartment of Urology, The First Affiliated Hospital of Zhengzhou UniversityInstitute of Biomedical Health Technology and Engineering, Shenzhen Bay LaboratoryInstitute of Biomedical Health Technology and Engineering, Shenzhen Bay LaboratoryDepartment of Urology, The First Affiliated Hospital of Zhengzhou UniversityInstitute of Biomedical Health Technology and Engineering, Shenzhen Bay LaboratoryDepartment of Urology, The First Affiliated Hospital of Zhengzhou UniversityAbstract Androgen deprivation therapy (ADT) is a crucial and effective strategy for prostate cancer, while systemic administration may cause profound side effects on normal tissues. More importantly, the ADT can easily lead to resistance by involving the activation of NF-κB signaling pathway and high infiltration of M2 macrophages in tumor microenvironment (TME). Herein, we developed a biomimetic nanotherapeutic platform by deriving cell membrane nanovesicles from cancer cells and probiotics to yield the hybrid cellular nanovesicles (hNVs), loading flutamide (Flu) into the resulting hNVs, and finally modifying the hNVs@Flu with Epigallocatechin-3-gallate (EGCG). In this nanotherapeutic platform, the hNVs significantly improved the accumulation of hNVs@Flu-EGCG in tumor sites and reprogramed immunosuppressive M2 macrophages into antitumorigenic M1 macrophages, the Flu acted on androgen receptors and inhibited tumor proliferation, and the EGCG promoted apoptosis of prostate cancer cells by inhibiting the NF-κB pathway, thus synergistically stimulating the antitumor immunity and reducing the side effects and resistance of ADT. In a prostate cancer mouse model, the hNVs@Flu-EGCG significantly extended the lifespan of mice with tumors and led to an 81.78% reduction in tumor growth compared with the untreated group. Overall, the hNVs@Flu-EGCG are safe, modifiable, and effective, thus offering a promising platform for effective therapeutics of prostate cancer. Graphical Abstracthttps://doi.org/10.1186/s12951-024-02458-9Prostate cancerAndrogen deprivation therapyImmunotherapyNanotechnologyBiomaterials |
| spellingShingle | Yiming Guo Jicheng Wu Lefan Chen Lujie Liu Tianxiang Bi Yuanwei Pan Qian-Fang Meng Chaoliang Wang Lang Rao Qi Li Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy Journal of Nanobiotechnology Prostate cancer Androgen deprivation therapy Immunotherapy Nanotechnology Biomaterials |
| title | Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy |
| title_full | Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy |
| title_fullStr | Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy |
| title_full_unstemmed | Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy |
| title_short | Tea polyphenol-engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy |
| title_sort | tea polyphenol engineered hybrid cellular nanovesicles for cancer immunotherapy and androgen deprivation therapy |
| topic | Prostate cancer Androgen deprivation therapy Immunotherapy Nanotechnology Biomaterials |
| url | https://doi.org/10.1186/s12951-024-02458-9 |
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