Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer
(1) <i>Background</i>: This study evaluated the clinical outcome after salvage radiotherapy for first pelvic relapse after endometrial cancer (EC). (2) <i>Methods</i>: This multicenter retrospective study included EC patients with first central pelvic relapse without lymph no...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/6/1367 |
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| author | Kristina Lindemann Elisabeth Smogeli Milada Cvancarova Småstuen Kjersti Bruheim Jone Trovik Terje Nordberg Gunnar B. Kristensen Henrica M. J. Werner Esten Nakken |
| author_facet | Kristina Lindemann Elisabeth Smogeli Milada Cvancarova Småstuen Kjersti Bruheim Jone Trovik Terje Nordberg Gunnar B. Kristensen Henrica M. J. Werner Esten Nakken |
| author_sort | Kristina Lindemann |
| collection | DOAJ |
| description | (1) <i>Background</i>: This study evaluated the clinical outcome after salvage radiotherapy for first pelvic relapse after endometrial cancer (EC). (2) <i>Methods</i>: This multicenter retrospective study included EC patients with first central pelvic relapse without lymph node involvement treated with curative intent. Progression-free (PFS) and overall survival (OS) were calculated with the Kaplan–Meier method and possible predictive factors for risk of relapse and mortality were identified using the Cox model. (3) <i>Results</i>: We included 139 patients with median EQD2 (Equivalent Dose in 2 Gy fractions) to the clinical target volume of 70.0 Gy. During follow up of median 6.66 years, 39.6% patients developed a second relapse. Risk group classification at primary diagnosis based on histology, grading and FIGO stage and how the pelvic tumor boost was administered were independently associated with PFS and OS. Five-year OS was 68% (95% CI (59–75)) for the whole cohort. Five-year OS was 88% (95% CI (75–94)), 72% (95% CI (55–84)) and 38% (95% CI (15–60)) for the stage I low-, intermediate- and high-risk group, respectively. (4) <i>Conclusions</i>: The majority of central pelvic recurrences in RT-naive EC women can be successfully salvaged with radiotherapy. However, survival in patients with high-risk disease remains poor and warrants a more individualized approach to optimize outcome. |
| first_indexed | 2024-03-10T13:07:51Z |
| format | Article |
| id | doaj.art-820bb98631c74005b50b7f520bd5adea |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:07:51Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-820bb98631c74005b50b7f520bd5adea2023-11-21T10:57:34ZengMDPI AGCancers2072-66942021-03-01136136710.3390/cancers13061367Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial CancerKristina Lindemann0Elisabeth Smogeli1Milada Cvancarova Småstuen2Kjersti Bruheim3Jone Trovik4Terje Nordberg5Gunnar B. Kristensen6Henrica M. J. Werner7Esten Nakken8Department of Gynecological Oncology, Division of Cancer Medicine, Oslo University Hospital, PB 4953 Nydalen, 0424 Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1171 Blindern, 0318 Oslo, NorwayDepartment of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0166 Oslo, NorwayDepartment of Oncology, Division of Cancer Medicine, Oslo University Hospital, PB 4953 Nydalen, 0424 Oslo, NorwayCentre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, 5020 Bergen, NorwayDepartment of Oncology, Haukeland University Hospital, 5021 Bergen, NorwayInstitute for Cancer Genetics and Informatics, Department of Oncology, Division of Cancer Medicine, Oslo University Hospital, 0424 Oslo, NorwayDepartment of Obstetrics and Gynecology, Grow School for Oncology and Developmental Biology, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ Maastricht, The NetherlandsDepartment of Oncology, Division of Cancer Medicine, Oslo University Hospital, PB 4953 Nydalen, 0424 Oslo, Norway(1) <i>Background</i>: This study evaluated the clinical outcome after salvage radiotherapy for first pelvic relapse after endometrial cancer (EC). (2) <i>Methods</i>: This multicenter retrospective study included EC patients with first central pelvic relapse without lymph node involvement treated with curative intent. Progression-free (PFS) and overall survival (OS) were calculated with the Kaplan–Meier method and possible predictive factors for risk of relapse and mortality were identified using the Cox model. (3) <i>Results</i>: We included 139 patients with median EQD2 (Equivalent Dose in 2 Gy fractions) to the clinical target volume of 70.0 Gy. During follow up of median 6.66 years, 39.6% patients developed a second relapse. Risk group classification at primary diagnosis based on histology, grading and FIGO stage and how the pelvic tumor boost was administered were independently associated with PFS and OS. Five-year OS was 68% (95% CI (59–75)) for the whole cohort. Five-year OS was 88% (95% CI (75–94)), 72% (95% CI (55–84)) and 38% (95% CI (15–60)) for the stage I low-, intermediate- and high-risk group, respectively. (4) <i>Conclusions</i>: The majority of central pelvic recurrences in RT-naive EC women can be successfully salvaged with radiotherapy. However, survival in patients with high-risk disease remains poor and warrants a more individualized approach to optimize outcome.https://www.mdpi.com/2072-6694/13/6/1367endometrial cancerpelvic relapsevaginal relapseoutcomesalvage radiation |
| spellingShingle | Kristina Lindemann Elisabeth Smogeli Milada Cvancarova Småstuen Kjersti Bruheim Jone Trovik Terje Nordberg Gunnar B. Kristensen Henrica M. J. Werner Esten Nakken Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer Cancers endometrial cancer pelvic relapse vaginal relapse outcome salvage radiation |
| title | Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer |
| title_full | Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer |
| title_fullStr | Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer |
| title_full_unstemmed | Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer |
| title_short | Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer |
| title_sort | salvage radiation for pelvic relapse after surgically treated endometrial cancer |
| topic | endometrial cancer pelvic relapse vaginal relapse outcome salvage radiation |
| url | https://www.mdpi.com/2072-6694/13/6/1367 |
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