SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury

SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury

Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury, coronary circulation is a so far neglected target of cardioprotection. In this study, we investigated the molecular mechanisms underlying I/R injury to cardiac microcirculation. Using gene delivery, we ana...

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Bibliographic Details
Main Authors:	Ying Tan, David Mui, Sam Toan, Pingjun Zhu, Ruibing Li, Hao Zhou
Format:	Article
Language:	English
Published:	Elsevier 2020-12-01
Series:	Molecular Therapy: Nucleic Acids
Subjects:	cardiac microvascular I/R injury XO ROS SERCA mitochondrial quality control
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253120302845

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