Parameters of ventricular repolarization in patients with autoimmune hepatitis
Objective: Autoimmune hepatitis (AIH) is a liver disorder that affects both children and adults. It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in the absence of known etiology. V...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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KARE Publishing
2017-06-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-57870 |
| _version_ | 1797912718277083136 |
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| author | Burak Açar Mahmut Yüksel Çağrı Yayla Özgür Kırbaş Sefa Ünal Ahmet Göktuğ Ertem Koray Demirtaş Mustafa Kaplan Meral Akdoğan Sabite Kaçar Ertuğrul Kayaçetin Sinan Aydoğdu |
| author_facet | Burak Açar Mahmut Yüksel Çağrı Yayla Özgür Kırbaş Sefa Ünal Ahmet Göktuğ Ertem Koray Demirtaş Mustafa Kaplan Meral Akdoğan Sabite Kaçar Ertuğrul Kayaçetin Sinan Aydoğdu |
| author_sort | Burak Açar |
| collection | DOAJ |
| description | Objective: Autoimmune hepatitis (AIH) is a liver disorder that affects both children and adults. It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in the absence of known etiology. Ventricular repolarization has been evaluated using T wave and QT interval measurements in patients with hepatic cirrhosis. Ventricular repolarization may be defined using QT interval, QT dispersion, and T wave measurements. Recently, it has been demonstrated that peak and end of the T wave (Tp-e) interval, Tp-e/QT, and Tp-e/corrected QT interval (QTc) ratios can be novel indicators for prediction of ventricular arrhythmias and mortality. In this study, an investigation of ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with AIH was performed.
Methods: Total of 31 patients with AIH and 31 controls were enrolled in the present study. Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were measured on 12-lead electrocardiogram.
Results: QT interval (378.9+-41.4 vs. 350.0+-22.7; p=0.001), QTc interval (396.8+-46.7 vs. 367.3+-34.9; p=0.039), Tp-e interval (68.2+-12.3 vs. 42.5+-6.8; p<0.001), Tp-e/QT ratio (0.18+-0.02 vs. 0.12+-0.01; p<0.001) and Tp-e/QTc ratio (0.17+-0.02 vs. 0.11+-0.01; p<0.001) were significantly higher in patients with AIH than control patients.
Conclusion: The results of the present study indicated that Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were greater in patients with AIH. |
| first_indexed | 2024-04-10T12:00:29Z |
| format | Article |
| id | doaj.art-820d8766eaaa40f189003b850493e3a6 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T12:00:29Z |
| publishDate | 2017-06-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-820d8766eaaa40f189003b850493e3a62023-02-15T16:16:37ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692017-06-0145433333810.5543/tkda.2017.57870TKDA-57870Parameters of ventricular repolarization in patients with autoimmune hepatitisBurak Açar0Mahmut Yüksel1Çağrı Yayla2Özgür Kırbaş3Sefa Ünal4Ahmet Göktuğ Ertem5Koray Demirtaş6Mustafa Kaplan7Meral Akdoğan8Sabite Kaçar9Ertuğrul Kayaçetin10Sinan Aydoğdu11Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, TurkeyTürkiye Yüksek Ihtisas Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey.Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, TurkeyTurkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, TurkeyTürkiye Yüksek Ihtisas Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey.Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey.Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey.Türkiye Yüksek Ihtisas Education and Research Hospital, Department of Gastroenterology, Ankara, Turkey.Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, TurkeyObjective: Autoimmune hepatitis (AIH) is a liver disorder that affects both children and adults. It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in the absence of known etiology. Ventricular repolarization has been evaluated using T wave and QT interval measurements in patients with hepatic cirrhosis. Ventricular repolarization may be defined using QT interval, QT dispersion, and T wave measurements. Recently, it has been demonstrated that peak and end of the T wave (Tp-e) interval, Tp-e/QT, and Tp-e/corrected QT interval (QTc) ratios can be novel indicators for prediction of ventricular arrhythmias and mortality. In this study, an investigation of ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with AIH was performed. Methods: Total of 31 patients with AIH and 31 controls were enrolled in the present study. Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were measured on 12-lead electrocardiogram. Results: QT interval (378.9+-41.4 vs. 350.0+-22.7; p=0.001), QTc interval (396.8+-46.7 vs. 367.3+-34.9; p=0.039), Tp-e interval (68.2+-12.3 vs. 42.5+-6.8; p<0.001), Tp-e/QT ratio (0.18+-0.02 vs. 0.12+-0.01; p<0.001) and Tp-e/QTc ratio (0.17+-0.02 vs. 0.11+-0.01; p<0.001) were significantly higher in patients with AIH than control patients. Conclusion: The results of the present study indicated that Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were greater in patients with AIH.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-57870autoimmune hepatitistp-e intervaltp-e/qt ratio |
| spellingShingle | Burak Açar Mahmut Yüksel Çağrı Yayla Özgür Kırbaş Sefa Ünal Ahmet Göktuğ Ertem Koray Demirtaş Mustafa Kaplan Meral Akdoğan Sabite Kaçar Ertuğrul Kayaçetin Sinan Aydoğdu Parameters of ventricular repolarization in patients with autoimmune hepatitis Türk Kardiyoloji Derneği Arşivi autoimmune hepatitis tp-e interval tp-e/qt ratio |
| title | Parameters of ventricular repolarization in patients with autoimmune hepatitis |
| title_full | Parameters of ventricular repolarization in patients with autoimmune hepatitis |
| title_fullStr | Parameters of ventricular repolarization in patients with autoimmune hepatitis |
| title_full_unstemmed | Parameters of ventricular repolarization in patients with autoimmune hepatitis |
| title_short | Parameters of ventricular repolarization in patients with autoimmune hepatitis |
| title_sort | parameters of ventricular repolarization in patients with autoimmune hepatitis |
| topic | autoimmune hepatitis tp-e interval tp-e/qt ratio |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-57870 |
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