Circulating tumour DNA for monitoring colorectal cancer—a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection

Circulating tumour DNA for monitoring colorectal cancer—a prospective cohort study to assess relationship to tissue methylation, cancer characteristics and surgical resection

Abstract Background Cell-free circulating tumour-derived DNA (ctDNA) can be detected by testing for methylated BCAT1 and IKZF1 DNA, which has proven sensitivity for colorectal cancer (CRC). A prospective correlative biomarker study between presence of methylated BCAT1 and IKZF1 in tissue and blood w...

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Bibliographic Details
Main Authors: Erin L. Symonds, Susanne K. Pedersen, David H. Murray, Maher Jedi, Susan E. Byrne, Philippa Rabbitt, Rohan T. Baker, Dawn Bastin, Graeme P. Young
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Clinical Epigenetics
Subjects:
Colorectal cancer
BCAT1
IKZF1
Methylation
Circulating tumour DNA
Surgical resection
Online Access:http://link.springer.com/article/10.1186/s13148-018-0500-5

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