Acute sirolimus overdose: a multicenter case series.
There are few data relating to sirolimus overdose in the medical literature. Our objectives were to describe all cases of overdose with sirolimus reported to Swiss, German and Austrian Poisons Centres between 2002-2013.An observational case-series analysis was performed to determine circumstances, m...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4447358?pdf=render |
| _version_ | 1811284308114014208 |
|---|---|
| author | Alessandro Ceschi Elja Heistermann Sonja Gros Cornelia Reichert Hugo Kupferschmidt Nicholas R Banner Stephan Krähenbühl Anne B Taegtmeyer |
| author_facet | Alessandro Ceschi Elja Heistermann Sonja Gros Cornelia Reichert Hugo Kupferschmidt Nicholas R Banner Stephan Krähenbühl Anne B Taegtmeyer |
| author_sort | Alessandro Ceschi |
| collection | DOAJ |
| description | There are few data relating to sirolimus overdose in the medical literature. Our objectives were to describe all cases of overdose with sirolimus reported to Swiss, German and Austrian Poisons Centres between 2002-2013.An observational case-series analysis was performed to determine circumstances, magnitude, management and outcome of sirolimus overdose.Five cases of acute sirolimus overdose were reported--three in young children and two in adults. Four were accidental and one was with suicidal intent. Two patients developed symptoms probably related to sirolimus overdose: mild elevation of alkaline phosphatase, fever and gastroenteritis in a 2.5-year-old male who ingested 3 mg, and mild changes in total cholesterol in an 18-year-old female after ingestion of 103 mg. None of these events were life-threatening. Serial blood concentration measurements were performed starting 24 h after ingestion of 103 mg in a single case, and these followed a similar pharmacokinetic time-course to measurements taken after dosing in the therapeutic range.Acute sirolimus overdose occurred accidentally in the majority of cases. Even large overdoses appeared to be well-tolerated, however children might be at greater risk of developing complications. Further study of sirolimus overdose is needed. |
| first_indexed | 2024-04-13T02:26:43Z |
| format | Article |
| id | doaj.art-8210ceb6616944d2a43933be2626085a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T02:26:43Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8210ceb6616944d2a43933be2626085a2022-12-22T03:06:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012803310.1371/journal.pone.0128033Acute sirolimus overdose: a multicenter case series.Alessandro CeschiElja HeistermannSonja GrosCornelia ReichertHugo KupferschmidtNicholas R BannerStephan KrähenbühlAnne B TaegtmeyerThere are few data relating to sirolimus overdose in the medical literature. Our objectives were to describe all cases of overdose with sirolimus reported to Swiss, German and Austrian Poisons Centres between 2002-2013.An observational case-series analysis was performed to determine circumstances, magnitude, management and outcome of sirolimus overdose.Five cases of acute sirolimus overdose were reported--three in young children and two in adults. Four were accidental and one was with suicidal intent. Two patients developed symptoms probably related to sirolimus overdose: mild elevation of alkaline phosphatase, fever and gastroenteritis in a 2.5-year-old male who ingested 3 mg, and mild changes in total cholesterol in an 18-year-old female after ingestion of 103 mg. None of these events were life-threatening. Serial blood concentration measurements were performed starting 24 h after ingestion of 103 mg in a single case, and these followed a similar pharmacokinetic time-course to measurements taken after dosing in the therapeutic range.Acute sirolimus overdose occurred accidentally in the majority of cases. Even large overdoses appeared to be well-tolerated, however children might be at greater risk of developing complications. Further study of sirolimus overdose is needed.http://europepmc.org/articles/PMC4447358?pdf=render |
| spellingShingle | Alessandro Ceschi Elja Heistermann Sonja Gros Cornelia Reichert Hugo Kupferschmidt Nicholas R Banner Stephan Krähenbühl Anne B Taegtmeyer Acute sirolimus overdose: a multicenter case series. PLoS ONE |
| title | Acute sirolimus overdose: a multicenter case series. |
| title_full | Acute sirolimus overdose: a multicenter case series. |
| title_fullStr | Acute sirolimus overdose: a multicenter case series. |
| title_full_unstemmed | Acute sirolimus overdose: a multicenter case series. |
| title_short | Acute sirolimus overdose: a multicenter case series. |
| title_sort | acute sirolimus overdose a multicenter case series |
| url | http://europepmc.org/articles/PMC4447358?pdf=render |
| work_keys_str_mv | AT alessandroceschi acutesirolimusoverdoseamulticentercaseseries AT eljaheistermann acutesirolimusoverdoseamulticentercaseseries AT sonjagros acutesirolimusoverdoseamulticentercaseseries AT corneliareichert acutesirolimusoverdoseamulticentercaseseries AT hugokupferschmidt acutesirolimusoverdoseamulticentercaseseries AT nicholasrbanner acutesirolimusoverdoseamulticentercaseseries AT stephankrahenbuhl acutesirolimusoverdoseamulticentercaseseries AT annebtaegtmeyer acutesirolimusoverdoseamulticentercaseseries |