Kinin B<sub>2</sub> Receptor Mediates Cisplatin-Induced Painful Peripheral Neuropathy by Intracellular Kinase Pathways and TRPA1 Channel Sensitisation

Kinin B<sub>2</sub> Receptor Mediates Cisplatin-Induced Painful Peripheral Neuropathy by Intracellular Kinase Pathways and TRPA1 Channel Sensitisation

Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology is poorly understood, it is known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1) channel play a significant role in the peripher...

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Bibliographic Details
Main Authors: Gabriela Becker, Maria Fernanda Pessano Fialho, Evelyne Silva Brum, Sara Marchesan Oliveira
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceuticals
Subjects:
neuropathic pain
allodynia
chemotherapy
CIPN
bradykinin
protein kinase Cε
Online Access:https://www.mdpi.com/1424-8247/16/7/959

Internet

https://www.mdpi.com/1424-8247/16/7/959

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