Efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancer
The study objective is to evaluate modern-era radiotherapy (external beam radiotherapy, EBRT) and target therapy (TT) outcomes for advanced medullary thyroid cancer (MTC).Materials and methods. Seventy eight consecutive patients with stage IV MTC were evaluated. All of them with relapsing locally ad...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2018-11-01
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| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/363 |
| _version_ | 1797876222419533824 |
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| author | A. D. Kaprin S. A. Ivanov F. E. Sevryukov I. S. Pimonova P. A. Isaev N. V. Severskaya A. A. Ilyin V. V. Polkin D. Yu. Siomin S. V. Vasilkov D. N. Derbugov Yu. A. Panaseikin V. S. Medvedev |
| author_facet | A. D. Kaprin S. A. Ivanov F. E. Sevryukov I. S. Pimonova P. A. Isaev N. V. Severskaya A. A. Ilyin V. V. Polkin D. Yu. Siomin S. V. Vasilkov D. N. Derbugov Yu. A. Panaseikin V. S. Medvedev |
| author_sort | A. D. Kaprin |
| collection | DOAJ |
| description | The study objective is to evaluate modern-era radiotherapy (external beam radiotherapy, EBRT) and target therapy (TT) outcomes for advanced medullary thyroid cancer (MTC).Materials and methods. Seventy eight consecutive patients with stage IV MTC were evaluated. All of them with relapsing locally advanced or metastatic MTC, 16 had clinically relevant mediastinal involvement, and 59 had distant metastasis; 26 patients received conformal EBRT or intensity-modulated radiotherapy in monomode, 16 patients – conformal EBRT with simultaneous TT with vandenanib, 36 patients – TT in monomode. Median EBRT dose was 60 Gy.Results. Kaplan–Meier estimates of the median overall survival rate was 14 months for radiotherapy in monomode, 48 months – for conformal EBRT + simultaneous TT with vandenanib, 50 months – for TT in monomode. EBRT and TT allows for significantly shorter periods (median 3.8 weeks), to relieve the symptoms of compression-mediated organs and structures of the neck and mediastinum than in the TT (median 10.2 weeks) (p <0.001).Conclusion. EBRT and TT provided durable locoregional disease control with limited morbidity. |
| first_indexed | 2024-04-10T01:58:45Z |
| format | Article |
| id | doaj.art-8211eea42f964127a82cb986f8c643a4 |
| institution | Directory Open Access Journal |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| last_indexed | 2024-04-10T01:58:45Z |
| publishDate | 2018-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj.art-8211eea42f964127a82cb986f8c643a42023-03-13T08:43:20ZrusABV-pressОпухоли головы и шеи2222-14682411-46342018-11-0183727610.17650/2222-1468-2018-8-3-72-76315Efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancerA. D. Kaprin0S. A. Ivanov1F. E. Sevryukov2I. S. Pimonova3P. A. Isaev4N. V. Severskaya5A. A. Ilyin6V. V. Polkin7D. Yu. Siomin8S. V. Vasilkov9D. N. Derbugov10Yu. A. Panaseikin11V. S. Medvedev12ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России.The study objective is to evaluate modern-era radiotherapy (external beam radiotherapy, EBRT) and target therapy (TT) outcomes for advanced medullary thyroid cancer (MTC).Materials and methods. Seventy eight consecutive patients with stage IV MTC were evaluated. All of them with relapsing locally advanced or metastatic MTC, 16 had clinically relevant mediastinal involvement, and 59 had distant metastasis; 26 patients received conformal EBRT or intensity-modulated radiotherapy in monomode, 16 patients – conformal EBRT with simultaneous TT with vandenanib, 36 patients – TT in monomode. Median EBRT dose was 60 Gy.Results. Kaplan–Meier estimates of the median overall survival rate was 14 months for radiotherapy in monomode, 48 months – for conformal EBRT + simultaneous TT with vandenanib, 50 months – for TT in monomode. EBRT and TT allows for significantly shorter periods (median 3.8 weeks), to relieve the symptoms of compression-mediated organs and structures of the neck and mediastinum than in the TT (median 10.2 weeks) (p <0.001).Conclusion. EBRT and TT provided durable locoregional disease control with limited morbidity.https://ogsh.abvpress.ru/jour/article/view/363дистанционная лучевая терапиятаргетная терапиявандетанибмедуллярный рак щитовидной железывыживаемость |
| spellingShingle | A. D. Kaprin S. A. Ivanov F. E. Sevryukov I. S. Pimonova P. A. Isaev N. V. Severskaya A. A. Ilyin V. V. Polkin D. Yu. Siomin S. V. Vasilkov D. N. Derbugov Yu. A. Panaseikin V. S. Medvedev Efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancer Опухоли головы и шеи дистанционная лучевая терапия таргетная терапия вандетаниб медуллярный рак щитовидной железы выживаемость |
| title | Efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancer |
| title_full | Efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancer |
| title_fullStr | Efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancer |
| title_full_unstemmed | Efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancer |
| title_short | Efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancer |
| title_sort | efficacy of external beam radiotherapy and targeted therapy with vandenanib in patients with inoperable and progressive medullary thyroid cancer |
| topic | дистанционная лучевая терапия таргетная терапия вандетаниб медуллярный рак щитовидной железы выживаемость |
| url | https://ogsh.abvpress.ru/jour/article/view/363 |
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