Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants

Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants

Background: Progressive retinal ganglion cell (RGC) dysfunction and death are common characteristics of retinal neurodegenerative diseases. Recently, hydroxycarboxylic acid receptor 1 (HCA<sub>1</sub>R, GPR81) was identified as a key modulator of mitochondrial function and cell survival....

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Main Authors: Rupali Vohra, Berta Sanz-Morello, Anna Luna Mølgaard Tams, Zaynab Ahmad Mouhammad, Kristine Karla Freude, Jens Hannibal, Blanca Irene Aldana, Linda Hildegaard Bergersen, Miriam Kolko
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
GPR81
HCA1
retina
retinal ganglion cells
cell death
lactate
Online Access:https://www.mdpi.com/2073-4409/11/13/2098

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