Transcriptional regulation in the development and dysfunction of neocortical projection neurons
Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas, and between the neocortex and other regions of the brain and spinal cord. Appropriate development of cortical projection neurons is regulated by certain e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=2;spage=246;epage=254;aulast=Wang |
| _version_ | 1827861763420323840 |
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| author | Ningxin Wang Rong Wan Ke Tang |
| author_facet | Ningxin Wang Rong Wan Ke Tang |
| author_sort | Ningxin Wang |
| collection | DOAJ |
| description | Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas, and between the neocortex and other regions of the brain and spinal cord. Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination, proliferation, specification, differentiation, migration, survival, axonogenesis, and synaptogenesis. These processes are precisely regulated in a tempo-spatial manner by intrinsic factors, extrinsic signals, and neural activities. The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions (such as sensory information integration, motor coordination, and cognition) but also to prevent the onset and progression of neurodevelopmental disorders (such as intellectual disability, autism spectrum disorders, anxiety, and depression). This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations. |
| first_indexed | 2024-03-12T13:44:10Z |
| format | Article |
| id | doaj.art-8212ee634e964e368f4d9f41732876db |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-03-12T13:44:10Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-8212ee634e964e368f4d9f41732876db2023-08-23T09:46:18ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742024-01-0119224625410.4103/1673-5374.379039Transcriptional regulation in the development and dysfunction of neocortical projection neuronsNingxin WangRong WanKe TangGlutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas, and between the neocortex and other regions of the brain and spinal cord. Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination, proliferation, specification, differentiation, migration, survival, axonogenesis, and synaptogenesis. These processes are precisely regulated in a tempo-spatial manner by intrinsic factors, extrinsic signals, and neural activities. The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions (such as sensory information integration, motor coordination, and cognition) but also to prevent the onset and progression of neurodevelopmental disorders (such as intellectual disability, autism spectrum disorders, anxiety, and depression). This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations.http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=2;spage=246;epage=254;aulast=Wangautism spectrum disorders; cognition; differentiation; excitatory circuits; intellectual disability; neocortex; neurodevelopmental disorders; projection neuron; specification; transcriptional regulation |
| spellingShingle | Ningxin Wang Rong Wan Ke Tang Transcriptional regulation in the development and dysfunction of neocortical projection neurons Neural Regeneration Research autism spectrum disorders; cognition; differentiation; excitatory circuits; intellectual disability; neocortex; neurodevelopmental disorders; projection neuron; specification; transcriptional regulation |
| title | Transcriptional regulation in the development and dysfunction of neocortical projection neurons |
| title_full | Transcriptional regulation in the development and dysfunction of neocortical projection neurons |
| title_fullStr | Transcriptional regulation in the development and dysfunction of neocortical projection neurons |
| title_full_unstemmed | Transcriptional regulation in the development and dysfunction of neocortical projection neurons |
| title_short | Transcriptional regulation in the development and dysfunction of neocortical projection neurons |
| title_sort | transcriptional regulation in the development and dysfunction of neocortical projection neurons |
| topic | autism spectrum disorders; cognition; differentiation; excitatory circuits; intellectual disability; neocortex; neurodevelopmental disorders; projection neuron; specification; transcriptional regulation |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=2;spage=246;epage=254;aulast=Wang |
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