Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital
Abstract Background Occupational exposure to chemotherapeutic agents in hospitals is a critical issue. Here, we focused on occupational exposure to platinum-based anti-cancer drugs (PDs) by evaluating platinum concentrations in hair and environmental workplace samples to monitor the risk among worke...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | Journal of Occupational Medicine and Toxicology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12995-020-00280-1 |
| _version_ | 1798041214653562880 |
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| author | Ai Hori Mari Shimura Yutaka Iida Kazuhiko Yamada Kyoko Nohara Takayuki Ichinose Ai Yamashita Junko Shirataki Shotaro Hagiwara |
| author_facet | Ai Hori Mari Shimura Yutaka Iida Kazuhiko Yamada Kyoko Nohara Takayuki Ichinose Ai Yamashita Junko Shirataki Shotaro Hagiwara |
| author_sort | Ai Hori |
| collection | DOAJ |
| description | Abstract Background Occupational exposure to chemotherapeutic agents in hospitals is a critical issue. Here, we focused on occupational exposure to platinum-based anti-cancer drugs (PDs) by evaluating platinum concentrations in hair and environmental workplace samples to monitor the risk among workers. Methods Hospital workers who dealt with or without PDs, patients treated with PDs, and non-medical office workers outside the hospital donated hair samples and completed a questionnaire regarding their history of handling PDs, including any incidents. Hair samples were collected and surface wipe sampling was performed in July 2010 and April 2015, before and after moving to a new building and introducing a revised safety program in August 2010. Samples were analyzed by inductively coupled plasma-mass spectrometry. Results Platinum concentrations in hair from PDs-handling workers was significantly higher than in non-PDs-handling workers (P = 0.045), although 50 times lower than that from PDs-treated patients. Platinum concentrations in the hospital environment had decreased at the second survey 5 years later but had not changed significantly in the hair samples from hospital workers. Conclusion Platinum concentrations in hair are likely dependent on the frequency of handling PDs. Reduced environmental contamination from PDs did not influence platinum levels in hospital workers’ hair. Continuous monitoring by measuring platinum concentrations in the environment and in hair would provide information regarding these issues. |
| first_indexed | 2024-04-11T22:18:22Z |
| format | Article |
| id | doaj.art-82139bb46e024baaadaf20fe7f8e923f |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-04-11T22:18:22Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-82139bb46e024baaadaf20fe7f8e923f2022-12-22T04:00:17ZengBMCJournal of Occupational Medicine and Toxicology1745-66732020-09-0115111110.1186/s12995-020-00280-1Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospitalAi Hori0Mari Shimura1Yutaka Iida2Kazuhiko Yamada3Kyoko Nohara4Takayuki Ichinose5Ai Yamashita6Junko Shirataki7Shotaro Hagiwara8Department of Epidemiology and Prevention, National Center for Global Health and Medicine (NCGM)Department of Intractable Diseases, NCGMInorganic Analysis Laboratories, Toray Research Center, Inc.Department of Surgery, Hospital, NCGMDepartment of Surgery, Hospital, NCGMInorganic Analysis Laboratories, Toray Research Center, Inc.Inorganic Analysis Laboratories, Toray Research Center, Inc.Inorganic Analysis Laboratories, Toray Research Center, Inc.Division of Hematology, Internal Medicine, Hospital, NCGMAbstract Background Occupational exposure to chemotherapeutic agents in hospitals is a critical issue. Here, we focused on occupational exposure to platinum-based anti-cancer drugs (PDs) by evaluating platinum concentrations in hair and environmental workplace samples to monitor the risk among workers. Methods Hospital workers who dealt with or without PDs, patients treated with PDs, and non-medical office workers outside the hospital donated hair samples and completed a questionnaire regarding their history of handling PDs, including any incidents. Hair samples were collected and surface wipe sampling was performed in July 2010 and April 2015, before and after moving to a new building and introducing a revised safety program in August 2010. Samples were analyzed by inductively coupled plasma-mass spectrometry. Results Platinum concentrations in hair from PDs-handling workers was significantly higher than in non-PDs-handling workers (P = 0.045), although 50 times lower than that from PDs-treated patients. Platinum concentrations in the hospital environment had decreased at the second survey 5 years later but had not changed significantly in the hair samples from hospital workers. Conclusion Platinum concentrations in hair are likely dependent on the frequency of handling PDs. Reduced environmental contamination from PDs did not influence platinum levels in hospital workers’ hair. Continuous monitoring by measuring platinum concentrations in the environment and in hair would provide information regarding these issues.http://link.springer.com/article/10.1186/s12995-020-00280-1PlatinumAnti-cancer drugHospitalHairInductively coupled plasma mass spectrometry |
| spellingShingle | Ai Hori Mari Shimura Yutaka Iida Kazuhiko Yamada Kyoko Nohara Takayuki Ichinose Ai Yamashita Junko Shirataki Shotaro Hagiwara Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital Journal of Occupational Medicine and Toxicology Platinum Anti-cancer drug Hospital Hair Inductively coupled plasma mass spectrometry |
| title | Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital |
| title_full | Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital |
| title_fullStr | Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital |
| title_full_unstemmed | Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital |
| title_short | Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital |
| title_sort | occupational exposure of platinum based anti cancer drugs five year monitoring of hair and environmental samples in a single hospital |
| topic | Platinum Anti-cancer drug Hospital Hair Inductively coupled plasma mass spectrometry |
| url | http://link.springer.com/article/10.1186/s12995-020-00280-1 |
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