Novel Technique of Endoscopic Ultrasonography for the Differential Diagnosis of Gallbladder Lesions and Intraductal Papillary Mucinous Neoplasms: A Single-Center Prospective Study
Detective flow imaging endoscopic ultrasonography (DFI-EUS) is an innovative imaging modality that was developed to detect fine vessels and low-velocity blood flow without contrast agents. We evaluate its utility for the differential diagnosis of gallbladder lesions and intraductal papillary mucinou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/13/2132 |
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| author | Yasunobu Yamashita Reiko Ashida Takaaki Tamura Toshio Shimokawa Hirofumi Yamazaki Yuki Kawaji Takashi Tamura Keiichi Hatamaru Masahiro Itonaga Masayuki Kitano |
| author_facet | Yasunobu Yamashita Reiko Ashida Takaaki Tamura Toshio Shimokawa Hirofumi Yamazaki Yuki Kawaji Takashi Tamura Keiichi Hatamaru Masahiro Itonaga Masayuki Kitano |
| author_sort | Yasunobu Yamashita |
| collection | DOAJ |
| description | Detective flow imaging endoscopic ultrasonography (DFI-EUS) is an innovative imaging modality that was developed to detect fine vessels and low-velocity blood flow without contrast agents. We evaluate its utility for the differential diagnosis of gallbladder lesions and intraductal papillary mucinous neoplasms (IPMNs). We enrolled patients who underwent DFI-EUS, e-FLOW EUS, and contrast-enhanced EUS for gallbladder lesions or IPMNs. The detection of vessels using DFI-EUS and e-FLOW EUS was compared with that via contrast-enhanced EUS and pathological findings. The vessel pattern was also categorized as regular or irregular. Of the 33 lesions included, there were final diagnoses of 13 IPMNs and 20 gallbladder lesions. DFI-EUS was significantly superior to e-FLOW EUS for discriminating between mural nodules and mucous clots and between solid gallbladder lesions and sludge using the presence or absence of vessel detection in lesions (<i>p</i> = 0.005). An irregular vessel pattern with DFI-EUS was a significant predictor of malignant gallbladder lesions (<i>p</i> = 0.002). DFI-EUS is more sensitive than e-FLOW-EUS for vessel detection and the differential diagnosis of gallbladder lesions and IPMNs. Vessel evaluation using DFI-EUS may be a useful and simple method for differentiating between mural nodules and mucous clots in IPMN, between solid gallbladder lesions and sludge, and between malignant and benign gallbladder lesions. |
| first_indexed | 2024-03-11T01:45:15Z |
| format | Article |
| id | doaj.art-82143d2c5a494b478f361fbbb7a4b810 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T01:45:15Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-82143d2c5a494b478f361fbbb7a4b8102023-11-18T16:20:26ZengMDPI AGDiagnostics2075-44182023-06-011313213210.3390/diagnostics13132132Novel Technique of Endoscopic Ultrasonography for the Differential Diagnosis of Gallbladder Lesions and Intraductal Papillary Mucinous Neoplasms: A Single-Center Prospective StudyYasunobu Yamashita0Reiko Ashida1Takaaki Tamura2Toshio Shimokawa3Hirofumi Yamazaki4Yuki Kawaji5Takashi Tamura6Keiichi Hatamaru7Masahiro Itonaga8Masayuki Kitano9Second Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-0012, JapanClinical Study Support Center, Wakayama Medical University Hospital, 811-1, Kimiidera, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-0012, JapanSecond Department of Internal Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-0012, JapanDetective flow imaging endoscopic ultrasonography (DFI-EUS) is an innovative imaging modality that was developed to detect fine vessels and low-velocity blood flow without contrast agents. We evaluate its utility for the differential diagnosis of gallbladder lesions and intraductal papillary mucinous neoplasms (IPMNs). We enrolled patients who underwent DFI-EUS, e-FLOW EUS, and contrast-enhanced EUS for gallbladder lesions or IPMNs. The detection of vessels using DFI-EUS and e-FLOW EUS was compared with that via contrast-enhanced EUS and pathological findings. The vessel pattern was also categorized as regular or irregular. Of the 33 lesions included, there were final diagnoses of 13 IPMNs and 20 gallbladder lesions. DFI-EUS was significantly superior to e-FLOW EUS for discriminating between mural nodules and mucous clots and between solid gallbladder lesions and sludge using the presence or absence of vessel detection in lesions (<i>p</i> = 0.005). An irregular vessel pattern with DFI-EUS was a significant predictor of malignant gallbladder lesions (<i>p</i> = 0.002). DFI-EUS is more sensitive than e-FLOW-EUS for vessel detection and the differential diagnosis of gallbladder lesions and IPMNs. Vessel evaluation using DFI-EUS may be a useful and simple method for differentiating between mural nodules and mucous clots in IPMN, between solid gallbladder lesions and sludge, and between malignant and benign gallbladder lesions.https://www.mdpi.com/2075-4418/13/13/2132detective flow imaging endoscopic ultrasonographyDoppler endoscopic ultrasonographynovel techniquegallbladder cancerintraductal papillary mucinous neoplasm |
| spellingShingle | Yasunobu Yamashita Reiko Ashida Takaaki Tamura Toshio Shimokawa Hirofumi Yamazaki Yuki Kawaji Takashi Tamura Keiichi Hatamaru Masahiro Itonaga Masayuki Kitano Novel Technique of Endoscopic Ultrasonography for the Differential Diagnosis of Gallbladder Lesions and Intraductal Papillary Mucinous Neoplasms: A Single-Center Prospective Study Diagnostics detective flow imaging endoscopic ultrasonography Doppler endoscopic ultrasonography novel technique gallbladder cancer intraductal papillary mucinous neoplasm |
| title | Novel Technique of Endoscopic Ultrasonography for the Differential Diagnosis of Gallbladder Lesions and Intraductal Papillary Mucinous Neoplasms: A Single-Center Prospective Study |
| title_full | Novel Technique of Endoscopic Ultrasonography for the Differential Diagnosis of Gallbladder Lesions and Intraductal Papillary Mucinous Neoplasms: A Single-Center Prospective Study |
| title_fullStr | Novel Technique of Endoscopic Ultrasonography for the Differential Diagnosis of Gallbladder Lesions and Intraductal Papillary Mucinous Neoplasms: A Single-Center Prospective Study |
| title_full_unstemmed | Novel Technique of Endoscopic Ultrasonography for the Differential Diagnosis of Gallbladder Lesions and Intraductal Papillary Mucinous Neoplasms: A Single-Center Prospective Study |
| title_short | Novel Technique of Endoscopic Ultrasonography for the Differential Diagnosis of Gallbladder Lesions and Intraductal Papillary Mucinous Neoplasms: A Single-Center Prospective Study |
| title_sort | novel technique of endoscopic ultrasonography for the differential diagnosis of gallbladder lesions and intraductal papillary mucinous neoplasms a single center prospective study |
| topic | detective flow imaging endoscopic ultrasonography Doppler endoscopic ultrasonography novel technique gallbladder cancer intraductal papillary mucinous neoplasm |
| url | https://www.mdpi.com/2075-4418/13/13/2132 |
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