Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes

Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes

The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease. Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) controls bone mineralization through the generation of pyrophosphate, and levels...

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Bibliographic Details
Main Authors: Carmen Huesa, Dongxing Zhu, James D. Glover, Mathieu Ferron, Gerard Karsenty, Elspeth M. Milne, José Luis Millan, S. Faisal Ahmed, Colin Farquharson, Nicholas M. Morton, Vicky E. MacRae
Format: Article
Language:English
Published: The Company of Biologists 2014-12-01
Series:Disease Models & Mechanisms
Subjects:
NPP1
Mineralization
Obesity
Diabetes
Online Access:http://dmm.biologists.org/content/7/12/1341

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