Dipyridamole activates adenosine A2B receptor and AMPK/cAMP signaling and promotes myogenic differentiation of myoblastic C2C12 cells

Dipyridamole activates adenosine A2B receptor and AMPK/cAMP signaling and promotes myogenic differentiation of myoblastic C2C12 cells

Introduction: Sarcopenia is defined as a loss of muscle mass and strength. ATP homeostasis is crucial during myogenesis. We determined how the purinergic system modulates myogenesis using dipyridamole (blocks adenosine taken up by the cells) and tenofovir (inhibits ATP release) in a myoblast cell li...

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Bibliographic Details
Main Authors: Miguel Marco-Bonilla, Raquel Herencia, María Fresnadillo, Fernando Huete-Toral, Gonzalo Carracedo, Raquel Largo, Gabriel Herrero-Beaumont, Aránzazu Mediero
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
Subjects:
adenosine
A2B receptor
muscle
sarcopenia
dipyridamole
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1247664/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1247664/full

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