Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report
Abstract Background Brain is one of the most common target organ of lung cancer metastasis, while descriptions of intraventricular carcinomatosis could hardly be found among previous cases. To date no cases from lung adenocarcinoma have been reported in the literature. Case presentation We report he...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12890-020-1168-0 |
| _version_ | 1818923537930387456 |
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| author | Chen Kong Dan Zhou Ning Wu Chong Bai |
| author_facet | Chen Kong Dan Zhou Ning Wu Chong Bai |
| author_sort | Chen Kong |
| collection | DOAJ |
| description | Abstract Background Brain is one of the most common target organ of lung cancer metastasis, while descriptions of intraventricular carcinomatosis could hardly be found among previous cases. To date no cases from lung adenocarcinoma have been reported in the literature. Case presentation We report here a case of multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation. This 64-year-old woman was referred to our hospital with complaints of dizziness and vomiting. Target therapy with afatinib was initiated and the lesions in both lung and brain achieved good partial responses. Conclusions This case report revealed a phenomenon of rare intraventricular metastasis from lung cancer, which should be carefully distinguished from primary ventricular tumors. Compared to brain parenchyma metastasis, intraventricular lesions would cause more severe symptoms which may be rapidly progressive. Target therapy could become a potential option in such patients with non-drugresistant EGFR mutations. |
| first_indexed | 2024-12-20T02:11:01Z |
| format | Article |
| id | doaj.art-821a247b789a45bf8b062a3c5495c57d |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-20T02:11:01Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-821a247b789a45bf8b062a3c5495c57d2022-12-21T19:57:03ZengBMCBMC Pulmonary Medicine1471-24662020-05-012011410.1186/s12890-020-1168-0Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case reportChen Kong0Dan Zhou1Ning Wu2Chong Bai3Department of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical UniversityDepartment of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical UniversityDepartment of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical UniversityDepartment of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical UniversityAbstract Background Brain is one of the most common target organ of lung cancer metastasis, while descriptions of intraventricular carcinomatosis could hardly be found among previous cases. To date no cases from lung adenocarcinoma have been reported in the literature. Case presentation We report here a case of multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation. This 64-year-old woman was referred to our hospital with complaints of dizziness and vomiting. Target therapy with afatinib was initiated and the lesions in both lung and brain achieved good partial responses. Conclusions This case report revealed a phenomenon of rare intraventricular metastasis from lung cancer, which should be carefully distinguished from primary ventricular tumors. Compared to brain parenchyma metastasis, intraventricular lesions would cause more severe symptoms which may be rapidly progressive. Target therapy could become a potential option in such patients with non-drugresistant EGFR mutations.http://link.springer.com/article/10.1186/s12890-020-1168-0Case reportIntraventricular metastasesLung adenocarcinomaTyrosine kinase inhibitor |
| spellingShingle | Chen Kong Dan Zhou Ning Wu Chong Bai Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report BMC Pulmonary Medicine Case report Intraventricular metastases Lung adenocarcinoma Tyrosine kinase inhibitor |
| title | Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report |
| title_full | Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report |
| title_fullStr | Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report |
| title_full_unstemmed | Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report |
| title_short | Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report |
| title_sort | multiple intraventricular metastases from lung adenocarcinoma with egfr g719x mutation a case report |
| topic | Case report Intraventricular metastases Lung adenocarcinoma Tyrosine kinase inhibitor |
| url | http://link.springer.com/article/10.1186/s12890-020-1168-0 |
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