The Role of Neural Signaling in the Pancreatic Cancer Microenvironment
Pancreatic cancer is one of the most lethal malignant diseases. Various cells in the tumor microenvironment interact with tumor cells and orchestrate to support tumor progression. Several kinds of nerves are found in the tumor microenvironment, and each plays an essential role in tumor biology. Rece...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/17/4269 |
| _version_ | 1797496033437024256 |
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| author | Ryota Takahashi Hideaki Ijichi Mitsuhiro Fujishiro |
| author_facet | Ryota Takahashi Hideaki Ijichi Mitsuhiro Fujishiro |
| author_sort | Ryota Takahashi |
| collection | DOAJ |
| description | Pancreatic cancer is one of the most lethal malignant diseases. Various cells in the tumor microenvironment interact with tumor cells and orchestrate to support tumor progression. Several kinds of nerves are found in the tumor microenvironment, and each plays an essential role in tumor biology. Recent studies have shown that sympathetic, parasympathetic, and sensory neurons are found in the pancreatic cancer microenvironment. Neural signaling not only targets neural cells, but tumor cells and immune cells via neural receptors expressed on these cells, through which tumor growth, inflammation, and anti-tumor immunity are affected. Thus, these broad-range effects of neural signaling in the pancreatic cancer microenvironment may represent novel therapeutic targets. The modulation of neural signaling may be a therapeutic strategy targeting the whole tumor microenvironment. In this review, we describe the current understanding of the role of nerves in the tumor microenvironment of various cancers, with an emphasis on pancreatic cancer. We also discuss the underlying mechanisms and the possibility of therapeutic applications. |
| first_indexed | 2024-03-10T01:57:56Z |
| format | Article |
| id | doaj.art-821a4feb2aab497cb51eb95788cebc41 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:57:56Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-821a4feb2aab497cb51eb95788cebc412023-11-23T12:52:40ZengMDPI AGCancers2072-66942022-08-011417426910.3390/cancers14174269The Role of Neural Signaling in the Pancreatic Cancer MicroenvironmentRyota Takahashi0Hideaki Ijichi1Mitsuhiro Fujishiro2Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, JapanDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, JapanPancreatic cancer is one of the most lethal malignant diseases. Various cells in the tumor microenvironment interact with tumor cells and orchestrate to support tumor progression. Several kinds of nerves are found in the tumor microenvironment, and each plays an essential role in tumor biology. Recent studies have shown that sympathetic, parasympathetic, and sensory neurons are found in the pancreatic cancer microenvironment. Neural signaling not only targets neural cells, but tumor cells and immune cells via neural receptors expressed on these cells, through which tumor growth, inflammation, and anti-tumor immunity are affected. Thus, these broad-range effects of neural signaling in the pancreatic cancer microenvironment may represent novel therapeutic targets. The modulation of neural signaling may be a therapeutic strategy targeting the whole tumor microenvironment. In this review, we describe the current understanding of the role of nerves in the tumor microenvironment of various cancers, with an emphasis on pancreatic cancer. We also discuss the underlying mechanisms and the possibility of therapeutic applications.https://www.mdpi.com/2072-6694/14/17/4269pancreatic ductal adenocarcinomatumor microenvironmentstromanerve |
| spellingShingle | Ryota Takahashi Hideaki Ijichi Mitsuhiro Fujishiro The Role of Neural Signaling in the Pancreatic Cancer Microenvironment Cancers pancreatic ductal adenocarcinoma tumor microenvironment stroma nerve |
| title | The Role of Neural Signaling in the Pancreatic Cancer Microenvironment |
| title_full | The Role of Neural Signaling in the Pancreatic Cancer Microenvironment |
| title_fullStr | The Role of Neural Signaling in the Pancreatic Cancer Microenvironment |
| title_full_unstemmed | The Role of Neural Signaling in the Pancreatic Cancer Microenvironment |
| title_short | The Role of Neural Signaling in the Pancreatic Cancer Microenvironment |
| title_sort | role of neural signaling in the pancreatic cancer microenvironment |
| topic | pancreatic ductal adenocarcinoma tumor microenvironment stroma nerve |
| url | https://www.mdpi.com/2072-6694/14/17/4269 |
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