CYTOKINES AND HISTOPATHOLOGIC PATTERN OF MALIGNANT NEOPLASMS IN GASTROINTESTINAL CANCER
The patients with gastrointestinal cancer exhibit high contents of TNFα, IL-1β, IL-2, IL-6, IL-8, IFNγ, IL-1Ra and increased levels of anti-IFNα antibodies. Significant correlations are detected between histopathological parameters of the tumors, and the levels of TNFα, IL-2, IL-6, IL-8, IFNα, IFNγ,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/42 |
| _version_ | 1826534394603503616 |
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| author | A. I. Autenshluss A. V. Sosnina E. S. Mikhailova D. V. Morozov N. A. Varaksin M. Yu. Rukavishnikov Yu. N. Kozlova A. V. Kan’shina |
| author_facet | A. I. Autenshluss A. V. Sosnina E. S. Mikhailova D. V. Morozov N. A. Varaksin M. Yu. Rukavishnikov Yu. N. Kozlova A. V. Kan’shina |
| author_sort | A. I. Autenshluss |
| collection | DOAJ |
| description | The patients with gastrointestinal cancer exhibit high contents of TNFα, IL-1β, IL-2, IL-6, IL-8, IFNγ, IL-1Ra and increased levels of anti-IFNα antibodies. Significant correlations are detected between histopathological parameters of the tumors, and the levels of TNFα, IL-2, IL-6, IL-8, IFNα, IFNγ, as well as antibodies against TNFα и IFNα. Moreover, we have determined diagnostically significant levels of cytokines and their combinations. On the basis of estimated diagnostic values, one may evaluate both current status of the tumor, as well as its potential malignancy grade. |
| first_indexed | 2024-03-08T05:51:43Z |
| format | Article |
| id | doaj.art-821b374d422a4da783a8805779aba27b |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:22:20Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-821b374d422a4da783a8805779aba27b2025-03-11T17:58:59ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01111293410.15789/1563-0625-2009-1-29-3441CYTOKINES AND HISTOPATHOLOGIC PATTERN OF MALIGNANT NEOPLASMS IN GASTROINTESTINAL CANCERA. I. Autenshluss0A. V. Sosnina1E. S. Mikhailova2D. V. Morozov3N. A. Varaksin4M. Yu. Rukavishnikov5Yu. N. Kozlova6A. V. Kan’shina7ГУ НИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскГУ НИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскГУ НИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскГУ НИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскЗАО «Вектор-Бест», п. Кольцово, Новосибирская областьЗАО «Вектор-Бест», п. Кольцово, Новосибирская областьГУ НИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскГУ НИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскThe patients with gastrointestinal cancer exhibit high contents of TNFα, IL-1β, IL-2, IL-6, IL-8, IFNγ, IL-1Ra and increased levels of anti-IFNα antibodies. Significant correlations are detected between histopathological parameters of the tumors, and the levels of TNFα, IL-2, IL-6, IL-8, IFNα, IFNγ, as well as antibodies against TNFα и IFNα. Moreover, we have determined diagnostically significant levels of cytokines and their combinations. On the basis of estimated diagnostic values, one may evaluate both current status of the tumor, as well as its potential malignancy grade.https://www.mimmun.ru/mimmun/article/view/42cytokinesantibodieshistopatologic patternmalignant neoplasmgastorintestinal cancer |
| spellingShingle | A. I. Autenshluss A. V. Sosnina E. S. Mikhailova D. V. Morozov N. A. Varaksin M. Yu. Rukavishnikov Yu. N. Kozlova A. V. Kan’shina CYTOKINES AND HISTOPATHOLOGIC PATTERN OF MALIGNANT NEOPLASMS IN GASTROINTESTINAL CANCER Медицинская иммунология cytokines antibodies histopatologic pattern malignant neoplasm gastorintestinal cancer |
| title | CYTOKINES AND HISTOPATHOLOGIC PATTERN OF MALIGNANT NEOPLASMS IN GASTROINTESTINAL CANCER |
| title_full | CYTOKINES AND HISTOPATHOLOGIC PATTERN OF MALIGNANT NEOPLASMS IN GASTROINTESTINAL CANCER |
| title_fullStr | CYTOKINES AND HISTOPATHOLOGIC PATTERN OF MALIGNANT NEOPLASMS IN GASTROINTESTINAL CANCER |
| title_full_unstemmed | CYTOKINES AND HISTOPATHOLOGIC PATTERN OF MALIGNANT NEOPLASMS IN GASTROINTESTINAL CANCER |
| title_short | CYTOKINES AND HISTOPATHOLOGIC PATTERN OF MALIGNANT NEOPLASMS IN GASTROINTESTINAL CANCER |
| title_sort | cytokines and histopathologic pattern of malignant neoplasms in gastrointestinal cancer |
| topic | cytokines antibodies histopatologic pattern malignant neoplasm gastorintestinal cancer |
| url | https://www.mimmun.ru/mimmun/article/view/42 |
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