Pain Perception and Migraine
Background: It is well-known that both inter- and intra-individual differences exist in the perception of pain; this is especially true in migraine, an elusive pain disorder of the head. Although electrophysiology and neuroimaging techniques have greatly contributed to a better understanding of the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00576/full |
| _version_ | 1818233919420497920 |
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| author | Antonio Russo Antonio Russo Gianluca Coppola Francesco Pierelli Francesco Pierelli Vincenzo Parisi Marcello Silvestro Alessandro Tessitore Alessandro Tessitore Gioacchino Tedeschi Gioacchino Tedeschi Gioacchino Tedeschi |
| author_facet | Antonio Russo Antonio Russo Gianluca Coppola Francesco Pierelli Francesco Pierelli Vincenzo Parisi Marcello Silvestro Alessandro Tessitore Alessandro Tessitore Gioacchino Tedeschi Gioacchino Tedeschi Gioacchino Tedeschi |
| author_sort | Antonio Russo |
| collection | DOAJ |
| description | Background: It is well-known that both inter- and intra-individual differences exist in the perception of pain; this is especially true in migraine, an elusive pain disorder of the head. Although electrophysiology and neuroimaging techniques have greatly contributed to a better understanding of the mechanisms involved in migraine during recent decades, the exact characteristics of pain threshold and pain intensity perception remain to be determined, and continue to be a matter of debate.Objective: The aim of this review is to provide a comprehensive overview of clinical, electrophysiological, and functional neuroimaging studies investigating changes during various phases of the so-called “migraine cycle” and in different migraine phenotypes, using pain threshold and pain intensity perception assessments.Methods: A systematic search for qualitative studies was conducted using search terms “migraine,” “pain,” “headache,” “temporal summation,” “quantitative sensory testing,” and “threshold,” alone and in combination (subject headings and keywords). The literature search was updated using the additional keywords “pain intensity,” and “neuroimaging” to identify full-text papers written in English and published in peer-reviewed journals, using PubMed and Google Scholar databases. In addition, we manually searched the reference lists of all research articles and review articles.Conclusion: Consistent data indicate that pain threshold is lower during the ictal phase than during the interictal phase of migraine or healthy controls in response to pressure, cold and heat stimuli. There is evidence for preictal sub-allodynia, whereas interictal results are conflicting due to either reduced or no observed difference in pain threshold. On the other hand, despite methodological limitations, converging observations support the concept that migraine attacks may be characterized by an increased pain intensity perception, which normalizes between episodes. Nevertheless, future studies are required to longitudinally evaluate a large group of patients before and after pharmacological and non-pharmacological interventions to investigate phases of the migraine cycle, clinical parameters of disease severity and chronic medication usage. |
| first_indexed | 2024-12-12T11:29:50Z |
| format | Article |
| id | doaj.art-821bd7a810614cdda2a06900707424fb |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T11:29:50Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-821bd7a810614cdda2a06900707424fb2022-12-22T00:25:49ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-08-01910.3389/fneur.2018.00576343622Pain Perception and MigraineAntonio Russo0Antonio Russo1Gianluca Coppola2Francesco Pierelli3Francesco Pierelli4Vincenzo Parisi5Marcello Silvestro6Alessandro Tessitore7Alessandro Tessitore8Gioacchino Tedeschi9Gioacchino Tedeschi10Gioacchino Tedeschi11Department of Medical, Surgical, Neurological, Metabolic, and Aging Sciences, Headache Center, University of Campania “Luigi Vanvitelli, ”, Naples, ItalyMRI Research Center SUN-FISM, University of Campania “Luigi Vanvitelli,”, Naples, ItalyResearch Unit of Neurophysiology of Vision and Neuro-Ophthalmology, G. B. Bietti Foundation-IRCCS, Rome, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, ItalyIRCCS Neuromed, Pozzilli, ItalyResearch Unit of Neurophysiology of Vision and Neuro-Ophthalmology, G. B. Bietti Foundation-IRCCS, Rome, ItalyDepartment of Medical, Surgical, Neurological, Metabolic, and Aging Sciences, Headache Center, University of Campania “Luigi Vanvitelli, ”, Naples, ItalyDepartment of Medical, Surgical, Neurological, Metabolic, and Aging Sciences, Headache Center, University of Campania “Luigi Vanvitelli, ”, Naples, ItalyMRI Research Center SUN-FISM, University of Campania “Luigi Vanvitelli,”, Naples, ItalyDepartment of Medical, Surgical, Neurological, Metabolic, and Aging Sciences, Headache Center, University of Campania “Luigi Vanvitelli, ”, Naples, ItalyMRI Research Center SUN-FISM, University of Campania “Luigi Vanvitelli,”, Naples, ItalyInstitute for Diagnosis and Care “Hermitage Capodimonte,”Naples, ItalyBackground: It is well-known that both inter- and intra-individual differences exist in the perception of pain; this is especially true in migraine, an elusive pain disorder of the head. Although electrophysiology and neuroimaging techniques have greatly contributed to a better understanding of the mechanisms involved in migraine during recent decades, the exact characteristics of pain threshold and pain intensity perception remain to be determined, and continue to be a matter of debate.Objective: The aim of this review is to provide a comprehensive overview of clinical, electrophysiological, and functional neuroimaging studies investigating changes during various phases of the so-called “migraine cycle” and in different migraine phenotypes, using pain threshold and pain intensity perception assessments.Methods: A systematic search for qualitative studies was conducted using search terms “migraine,” “pain,” “headache,” “temporal summation,” “quantitative sensory testing,” and “threshold,” alone and in combination (subject headings and keywords). The literature search was updated using the additional keywords “pain intensity,” and “neuroimaging” to identify full-text papers written in English and published in peer-reviewed journals, using PubMed and Google Scholar databases. In addition, we manually searched the reference lists of all research articles and review articles.Conclusion: Consistent data indicate that pain threshold is lower during the ictal phase than during the interictal phase of migraine or healthy controls in response to pressure, cold and heat stimuli. There is evidence for preictal sub-allodynia, whereas interictal results are conflicting due to either reduced or no observed difference in pain threshold. On the other hand, despite methodological limitations, converging observations support the concept that migraine attacks may be characterized by an increased pain intensity perception, which normalizes between episodes. Nevertheless, future studies are required to longitudinally evaluate a large group of patients before and after pharmacological and non-pharmacological interventions to investigate phases of the migraine cycle, clinical parameters of disease severity and chronic medication usage.https://www.frontiersin.org/article/10.3389/fneur.2018.00576/fullmigraineheadachepain processingpain measurementpain thresholdpain intensity perception |
| spellingShingle | Antonio Russo Antonio Russo Gianluca Coppola Francesco Pierelli Francesco Pierelli Vincenzo Parisi Marcello Silvestro Alessandro Tessitore Alessandro Tessitore Gioacchino Tedeschi Gioacchino Tedeschi Gioacchino Tedeschi Pain Perception and Migraine Frontiers in Neurology migraine headache pain processing pain measurement pain threshold pain intensity perception |
| title | Pain Perception and Migraine |
| title_full | Pain Perception and Migraine |
| title_fullStr | Pain Perception and Migraine |
| title_full_unstemmed | Pain Perception and Migraine |
| title_short | Pain Perception and Migraine |
| title_sort | pain perception and migraine |
| topic | migraine headache pain processing pain measurement pain threshold pain intensity perception |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00576/full |
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