Exploring neuronal bistability at the depolarization block.
Many neurons display bistability--coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3416767?pdf=render |
| _version_ | 1819041855664291840 |
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| author | Andrey Dovzhenok Alexey S Kuznetsov |
| author_facet | Andrey Dovzhenok Alexey S Kuznetsov |
| author_sort | Andrey Dovzhenok |
| collection | DOAJ |
| description | Many neurons display bistability--coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to elicit long-lasting changes in firing. In this paper, we focus on bistability that allows for a choice between tonic spiking and depolarization block in a wide range of the depolarization levels. We consider the spike-producing currents in two neurons, models of which differ by the parameter values. Our dopaminergic neuron model displays bistability in a wide range of applied currents at the depolarization block. The Hodgkin-Huxley model of the squid giant axon shows no bistability. We varied parameter values for the model to analyze transitions between the two parameter sets. We show that bistability primarily characterizes the inactivation of the Na(+) current. Our study suggests a connection between the amount of the Na(+) window current and the length of the bistability range. For the dopaminergic neuron we hypothesize that bistability can be linked to a prolonged action of antipsychotic drugs. |
| first_indexed | 2024-12-21T09:31:38Z |
| format | Article |
| id | doaj.art-821ea336208c481c9293e66bdf32cc4c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T09:31:38Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-821ea336208c481c9293e66bdf32cc4c2022-12-21T19:08:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4281110.1371/journal.pone.0042811Exploring neuronal bistability at the depolarization block.Andrey DovzhenokAlexey S KuznetsovMany neurons display bistability--coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to elicit long-lasting changes in firing. In this paper, we focus on bistability that allows for a choice between tonic spiking and depolarization block in a wide range of the depolarization levels. We consider the spike-producing currents in two neurons, models of which differ by the parameter values. Our dopaminergic neuron model displays bistability in a wide range of applied currents at the depolarization block. The Hodgkin-Huxley model of the squid giant axon shows no bistability. We varied parameter values for the model to analyze transitions between the two parameter sets. We show that bistability primarily characterizes the inactivation of the Na(+) current. Our study suggests a connection between the amount of the Na(+) window current and the length of the bistability range. For the dopaminergic neuron we hypothesize that bistability can be linked to a prolonged action of antipsychotic drugs.http://europepmc.org/articles/PMC3416767?pdf=render |
| spellingShingle | Andrey Dovzhenok Alexey S Kuznetsov Exploring neuronal bistability at the depolarization block. PLoS ONE |
| title | Exploring neuronal bistability at the depolarization block. |
| title_full | Exploring neuronal bistability at the depolarization block. |
| title_fullStr | Exploring neuronal bistability at the depolarization block. |
| title_full_unstemmed | Exploring neuronal bistability at the depolarization block. |
| title_short | Exploring neuronal bistability at the depolarization block. |
| title_sort | exploring neuronal bistability at the depolarization block |
| url | http://europepmc.org/articles/PMC3416767?pdf=render |
| work_keys_str_mv | AT andreydovzhenok exploringneuronalbistabilityatthedepolarizationblock AT alexeyskuznetsov exploringneuronalbistabilityatthedepolarizationblock |