Ultrasound-Mediated Blood–Brain Barrier Disruption for Drug Delivery: A Systematic Review of Protocols, Efficacy, and Safety Outcomes from Preclinical and Clinical Studies

Ultrasound-Mediated Blood–Brain Barrier Disruption for Drug Delivery: A Systematic Review of Protocols, Efficacy, and Safety Outcomes from Preclinical and Clinical Studies

Ultrasound-mediated blood–brain barrier (BBB) disruption has garnered focus as a method of delivering normally impenetrable drugs into the brain. Numerous studies have investigated this approach, and a diverse set of ultrasound parameters appear to influence the efficacy and safety of this approach....

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Bibliographic Details
Main Authors: Kushan Gandhi, Anita Barzegar-Fallah, Ashik Banstola, Shakila B. Rizwan, John N. J. Reynolds
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
focused ultrasound
blood–brain barrier opening
therapeutic agent delivery
ultrasound parameters
ultrasound safety
review
Online Access:https://www.mdpi.com/1999-4923/14/4/833

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https://www.mdpi.com/1999-4923/14/4/833

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