Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer
Thyroid cancer is the most common endocrine cancer. There is no systematic screening for such cancer, and the current challenge is to find potential biomarkers to facilitate an early diagnosis. Copper (Cu) and zinc (Zn) are essential micronutrients involved in the proper functioning of the thyroid g...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.698167/full |
| _version_ | 1819115721351757824 |
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| author | Latifa Sarra Kazi Tani Latifa Sarra Kazi Tani Alexandra T. Gourlan Nouria Dennouni-Medjati Philippe Telouk Majda Dali-Sahi Yahia Harek Qian Sun Julian Hackler Moussa Belhadj Lutz Schomburg Laurent Charlet |
| author_facet | Latifa Sarra Kazi Tani Latifa Sarra Kazi Tani Alexandra T. Gourlan Nouria Dennouni-Medjati Philippe Telouk Majda Dali-Sahi Yahia Harek Qian Sun Julian Hackler Moussa Belhadj Lutz Schomburg Laurent Charlet |
| author_sort | Latifa Sarra Kazi Tani |
| collection | DOAJ |
| description | Thyroid cancer is the most common endocrine cancer. There is no systematic screening for such cancer, and the current challenge is to find potential biomarkers to facilitate an early diagnosis. Copper (Cu) and zinc (Zn) are essential micronutrients involved in the proper functioning of the thyroid gland, and changes in their concentrations have been observed in the development of cancer. Previous studies have highlighted the potential 65Cu/63Cu ratio (δ65Cu) to be a cancer biomarker. This study tests its sensitivity on plasma samples (n = 46) of Algerian patients with papillary thyroid carcinoma and a set of corresponding biopsies (n = 11). The δ65Cu ratio in blood and tumor samples was determined using multi collector inductively coupled plasma-mass spectrometry (MC-ICP-MS), and their corresponding Cu and Zn plasma total concentrations using total reflection X-ray fluorescence (TXRF). Plasma concentrations of Cu were significantly higher (1346.1 ± 328.3 vs. 1060.5 ± 216.1 μg/L, p < 0.0001), and Zn significantly lower (942.1 ± 205.2 vs. 1027.9 ± 151.4 μg/L, p < 0.05) in thyroid cancer patients as compared to healthy controls (n = 50). Accordingly, the Cu/Zn ratio was significantly different between patients and controls (1.5 ± 0.4 vs. 1.0 ± 0.3, p < 0.0001). Furthermore, the δ65Cu plasma levels of patients were significantly lower than healthy controls (p < 0.0001), whereas thyroid tumor tissues presented high δ65Cu values. These results support the hypothesis that Cu isotopes and plasma trace elements may serve as suitable biomarkers of thyroid cancer diagnosis. |
| first_indexed | 2024-12-22T05:05:42Z |
| format | Article |
| id | doaj.art-821f1a46f2d84caeb886f161c490dc4e |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-22T05:05:42Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-821f1a46f2d84caeb886f161c490dc4e2022-12-21T18:38:07ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-09-01810.3389/fmed.2021.698167698167Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid CancerLatifa Sarra Kazi Tani0Latifa Sarra Kazi Tani1Alexandra T. Gourlan2Nouria Dennouni-Medjati3Philippe Telouk4Majda Dali-Sahi5Yahia Harek6Qian Sun7Julian Hackler8Moussa Belhadj9Lutz Schomburg10Laurent Charlet11Analytical Chemistry and Electrochemistry Laboratory, University of Abou Bekr Belkaid, Tlemcen, AlgeriaISTerre: Institut des Sciences de la Terre, Université Grenoble-Alpes, Université de Savoie Mont-Blanc, CNRS, IRD, IFSTTAR, Grenoble, FranceISTerre: Institut des Sciences de la Terre, Université Grenoble-Alpes, Université de Savoie Mont-Blanc, CNRS, IRD, IFSTTAR, Grenoble, FranceAnalytical Chemistry and Electrochemistry Laboratory, University of Abou Bekr Belkaid, Tlemcen, AlgeriaEcole Normale Superieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Lyon, FranceAnalytical Chemistry and Electrochemistry Laboratory, University of Abou Bekr Belkaid, Tlemcen, AlgeriaAnalytical Chemistry and Electrochemistry Laboratory, University of Abou Bekr Belkaid, Tlemcen, AlgeriaInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, GermanyInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, GermanyAnalytical Chemistry and Electrochemistry Laboratory, University of Abou Bekr Belkaid, Tlemcen, AlgeriaInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, GermanyISTerre: Institut des Sciences de la Terre, Université Grenoble-Alpes, Université de Savoie Mont-Blanc, CNRS, IRD, IFSTTAR, Grenoble, FranceThyroid cancer is the most common endocrine cancer. There is no systematic screening for such cancer, and the current challenge is to find potential biomarkers to facilitate an early diagnosis. Copper (Cu) and zinc (Zn) are essential micronutrients involved in the proper functioning of the thyroid gland, and changes in their concentrations have been observed in the development of cancer. Previous studies have highlighted the potential 65Cu/63Cu ratio (δ65Cu) to be a cancer biomarker. This study tests its sensitivity on plasma samples (n = 46) of Algerian patients with papillary thyroid carcinoma and a set of corresponding biopsies (n = 11). The δ65Cu ratio in blood and tumor samples was determined using multi collector inductively coupled plasma-mass spectrometry (MC-ICP-MS), and their corresponding Cu and Zn plasma total concentrations using total reflection X-ray fluorescence (TXRF). Plasma concentrations of Cu were significantly higher (1346.1 ± 328.3 vs. 1060.5 ± 216.1 μg/L, p < 0.0001), and Zn significantly lower (942.1 ± 205.2 vs. 1027.9 ± 151.4 μg/L, p < 0.05) in thyroid cancer patients as compared to healthy controls (n = 50). Accordingly, the Cu/Zn ratio was significantly different between patients and controls (1.5 ± 0.4 vs. 1.0 ± 0.3, p < 0.0001). Furthermore, the δ65Cu plasma levels of patients were significantly lower than healthy controls (p < 0.0001), whereas thyroid tumor tissues presented high δ65Cu values. These results support the hypothesis that Cu isotopes and plasma trace elements may serve as suitable biomarkers of thyroid cancer diagnosis.https://www.frontiersin.org/articles/10.3389/fmed.2021.698167/fullcopperisotopeszincbiomarkersthyroid cancer |
| spellingShingle | Latifa Sarra Kazi Tani Latifa Sarra Kazi Tani Alexandra T. Gourlan Nouria Dennouni-Medjati Philippe Telouk Majda Dali-Sahi Yahia Harek Qian Sun Julian Hackler Moussa Belhadj Lutz Schomburg Laurent Charlet Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer Frontiers in Medicine copper isotopes zinc biomarkers thyroid cancer |
| title | Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer |
| title_full | Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer |
| title_fullStr | Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer |
| title_full_unstemmed | Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer |
| title_short | Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer |
| title_sort | copper isotopes and copper to zinc ratio as possible biomarkers for thyroid cancer |
| topic | copper isotopes zinc biomarkers thyroid cancer |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.698167/full |
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