First and second kidney transplantations from living donors offer comparable outcomes for patients
Background : Increasingly many patients are being relisted for repeat kidney transplantation due to longer survival times after transplantation. This study compared the outcomes of second living donor kidney transplantations (LDKTs) with those of first LDKTs. Methods : Data were collected retrospect...
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| Format: | Article |
| Language: | English |
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Korean Society for Transplantation
2022-09-01
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| Series: | Korean Journal of Transplantation |
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| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.22.0018 |
| _version_ | 1797334479758426112 |
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| author | Namkee Oh Min Jung Kim Kyo Won Lee Hyun Cho Sook Young Woo Jinsoo Rhu Seunghwan Lee Jong Man Kim Gyu-Seong Choi Jae Berm Park Jae-Won Joh |
| author_facet | Namkee Oh Min Jung Kim Kyo Won Lee Hyun Cho Sook Young Woo Jinsoo Rhu Seunghwan Lee Jong Man Kim Gyu-Seong Choi Jae Berm Park Jae-Won Joh |
| author_sort | Namkee Oh |
| collection | DOAJ |
| description | Background : Increasingly many patients are being relisted for repeat kidney transplantation due to longer survival times after transplantation. This study compared the outcomes of second living donor kidney transplantations (LDKTs) with those of first LDKTs. Methods : Data were collected retrospectively for 1,429 LDKTs performed from 1995 to 2020 at Samsung Medical Center. The demographics of recipients and donors, immunologic factors, and outcomes of second LDKTs were compared to those of first LDKTs. Results : Among 1,429 cases of LDKT, 1,355 were first LDKT cases and 74 were second LDKT cases. Basic demographic data were comparable for the two groups of patients. The 5- and 10-year graft survival rates were 94% and 84% for first LDKTs and 96% and 86% for second LDKTs, respectively, with neither difference statistically significant (P=0.399). The 5- and 10-year patient survival rates were 98% and 94% for the first and 96% and 93% for the second LDKTs, respectively; neither difference was statistically significant (P=0.766). Multivariate analysis confirmed that a history of previous transplantation was not a statistically significant risk factor for graft loss (hazard ratio [HR], 0.83; P=0.677) or patient death (HR, 1.68; P=0.396). Conclusions: These results indicate that repeat kidney transplantation from living donors is a reasonable choice for patients who have experienced graft loss. |
| first_indexed | 2024-03-08T08:21:21Z |
| format | Article |
| id | doaj.art-821fde9bbed14805a7428a20413048aa |
| institution | Directory Open Access Journal |
| issn | 2671-8790 |
| language | English |
| last_indexed | 2024-03-08T08:21:21Z |
| publishDate | 2022-09-01 |
| publisher | Korean Society for Transplantation |
| record_format | Article |
| series | Korean Journal of Transplantation |
| spelling | doaj.art-821fde9bbed14805a7428a20413048aa2024-02-02T05:34:03ZengKorean Society for TransplantationKorean Journal of Transplantation2671-87902022-09-0136317317910.4285/kjt.22.0018kjt.22.0018First and second kidney transplantations from living donors offer comparable outcomes for patientsNamkee Oh0Min Jung Kim1Kyo Won Lee2Hyun Cho3Sook Young Woo4Jinsoo Rhu5Seunghwan Lee6Jong Man Kim7Gyu-Seong Choi8Jae Berm Park9Jae-Won Joh10Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Seoul Medical Center, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Statistics and Data Center, Samsung Medical Center, Seoul, KoreaDepartment of Statistics and Data Center, Samsung Medical Center, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Kyung Hee University Hospital at Gangdong, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground : Increasingly many patients are being relisted for repeat kidney transplantation due to longer survival times after transplantation. This study compared the outcomes of second living donor kidney transplantations (LDKTs) with those of first LDKTs. Methods : Data were collected retrospectively for 1,429 LDKTs performed from 1995 to 2020 at Samsung Medical Center. The demographics of recipients and donors, immunologic factors, and outcomes of second LDKTs were compared to those of first LDKTs. Results : Among 1,429 cases of LDKT, 1,355 were first LDKT cases and 74 were second LDKT cases. Basic demographic data were comparable for the two groups of patients. The 5- and 10-year graft survival rates were 94% and 84% for first LDKTs and 96% and 86% for second LDKTs, respectively, with neither difference statistically significant (P=0.399). The 5- and 10-year patient survival rates were 98% and 94% for the first and 96% and 93% for the second LDKTs, respectively; neither difference was statistically significant (P=0.766). Multivariate analysis confirmed that a history of previous transplantation was not a statistically significant risk factor for graft loss (hazard ratio [HR], 0.83; P=0.677) or patient death (HR, 1.68; P=0.396). Conclusions: These results indicate that repeat kidney transplantation from living donors is a reasonable choice for patients who have experienced graft loss.http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.22.0018kidney transplantation; renal transplantation; living donors; graft survival |
| spellingShingle | Namkee Oh Min Jung Kim Kyo Won Lee Hyun Cho Sook Young Woo Jinsoo Rhu Seunghwan Lee Jong Man Kim Gyu-Seong Choi Jae Berm Park Jae-Won Joh First and second kidney transplantations from living donors offer comparable outcomes for patients Korean Journal of Transplantation kidney transplantation; renal transplantation; living donors; graft survival |
| title | First and second kidney transplantations from living donors offer comparable outcomes for patients |
| title_full | First and second kidney transplantations from living donors offer comparable outcomes for patients |
| title_fullStr | First and second kidney transplantations from living donors offer comparable outcomes for patients |
| title_full_unstemmed | First and second kidney transplantations from living donors offer comparable outcomes for patients |
| title_short | First and second kidney transplantations from living donors offer comparable outcomes for patients |
| title_sort | first and second kidney transplantations from living donors offer comparable outcomes for patients |
| topic | kidney transplantation; renal transplantation; living donors; graft survival |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.22.0018 |
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