FDG‐PET/CT‐guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma
Aim The purpose of the study was to evaluate the clinical impact of fluorodeoxyglucose‐positron emission tomography/computed tomography (FDG‐PET/CT) followed by a new biopsy from the site with maximum standardized uptake value (SUVmax) in case of high maximal SUV values, in detecting clinically unsu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.4924 |
| _version_ | 1828061895499710464 |
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| author | Aino Rajamäki Hanne Kuitunen Marc Sorigue Salla‐Maarit Kokkonen Outi Kuittinen Kaisa Sunela |
| author_facet | Aino Rajamäki Hanne Kuitunen Marc Sorigue Salla‐Maarit Kokkonen Outi Kuittinen Kaisa Sunela |
| author_sort | Aino Rajamäki |
| collection | DOAJ |
| description | Aim The purpose of the study was to evaluate the clinical impact of fluorodeoxyglucose‐positron emission tomography/computed tomography (FDG‐PET/CT) followed by a new biopsy from the site with maximum standardized uptake value (SUVmax) in case of high maximal SUV values, in detecting clinically unsuspected histologic transformations (HT) of follicular lymphoma (FL). Methods This retrospective study included all the patients who had undergone FDG‐PET/CT during primary diagnosis or relapse of FL between 2010 and 2020 at Oulu University Hospital. Results The diagnosis changed from an indolent disease to a transformed lymphoma in >10% (7/63) of the patients who underwent diagnostic FDG‐PET/CT. The HT risk associated with high SUVmax (>10) was 24% (7 of 29 performed biopsies). Four out of these seven patients with verified HT had no previous clinical suspicion of transformation. Conclusion Our results suggest that a rebiopsy based on a high SUVmax in diagnostic FDG‐PET/CT is valuable in detecting clinically unsuspected HT of FL. |
| first_indexed | 2024-04-10T22:22:02Z |
| format | Article |
| id | doaj.art-8221514b5e3c4a67bca10038139e495f |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T22:22:02Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-8221514b5e3c4a67bca10038139e495f2023-01-17T17:10:24ZengWileyCancer Medicine2045-76342023-01-0112140741110.1002/cam4.4924FDG‐PET/CT‐guided rebiopsy may find clinically unsuspicious transformation of follicular lymphomaAino Rajamäki0Hanne Kuitunen1Marc Sorigue2Salla‐Maarit Kokkonen3Outi Kuittinen4Kaisa Sunela5Department of Oncology Hospital Nova of Central Finland Jyväskylä FinlandDepartment of Oncology Oulu University Hospital Oulu FinlandDepartment of Hematology ICO‐Hospital Germans Trias i Pujol, Functional cytomics‐IJC Badalona SpainDepartment of Nuclear Medicine Oulu University Hospital Oulu FinlandInstitute of Clinical Medicine, Faculty of Health Medicine University of Eastern Finland Kuopio FinlandDepartment of Oncology, Tays Cancer Center Tampere University Hospital Tampere FinlandAim The purpose of the study was to evaluate the clinical impact of fluorodeoxyglucose‐positron emission tomography/computed tomography (FDG‐PET/CT) followed by a new biopsy from the site with maximum standardized uptake value (SUVmax) in case of high maximal SUV values, in detecting clinically unsuspected histologic transformations (HT) of follicular lymphoma (FL). Methods This retrospective study included all the patients who had undergone FDG‐PET/CT during primary diagnosis or relapse of FL between 2010 and 2020 at Oulu University Hospital. Results The diagnosis changed from an indolent disease to a transformed lymphoma in >10% (7/63) of the patients who underwent diagnostic FDG‐PET/CT. The HT risk associated with high SUVmax (>10) was 24% (7 of 29 performed biopsies). Four out of these seven patients with verified HT had no previous clinical suspicion of transformation. Conclusion Our results suggest that a rebiopsy based on a high SUVmax in diagnostic FDG‐PET/CT is valuable in detecting clinically unsuspected HT of FL.https://doi.org/10.1002/cam4.4924FDG‐PET/CTfollicular lymphomahistologic transformationindolent lymphomaSUVmax |
| spellingShingle | Aino Rajamäki Hanne Kuitunen Marc Sorigue Salla‐Maarit Kokkonen Outi Kuittinen Kaisa Sunela FDG‐PET/CT‐guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma Cancer Medicine FDG‐PET/CT follicular lymphoma histologic transformation indolent lymphoma SUVmax |
| title | FDG‐PET/CT‐guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma |
| title_full | FDG‐PET/CT‐guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma |
| title_fullStr | FDG‐PET/CT‐guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma |
| title_full_unstemmed | FDG‐PET/CT‐guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma |
| title_short | FDG‐PET/CT‐guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma |
| title_sort | fdg pet ct guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma |
| topic | FDG‐PET/CT follicular lymphoma histologic transformation indolent lymphoma SUVmax |
| url | https://doi.org/10.1002/cam4.4924 |
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