Expression and Significance of COX-2 and its Transcription Factors NFAT3 and c-Jun in Non-small Cell Lung Cancer
Background and objective Cyclooxygenases (COX), the key enzymes in the conversion of arachidonic acid (AA) to prostaglandins (PGs), are involved in initiation and progression of cancer. The aim of this study is to explore the relationship between the expressions of COX-2 and several transcription fa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2010-11-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2010.11.07 |
| Summary: | Background and objective Cyclooxygenases (COX), the key enzymes in the conversion of arachidonic acid (AA) to prostaglandins (PGs), are involved in initiation and progression of cancer. The aim of this study is to explore the relationship between the expressions of COX-2 and several transcription factors in non-small cell lung cancer. Methods Immunohistochemistry was performed to assay the expression levels of COX-2, c-Fos, c-Jun and nuclear factor of activated T cells 3 (NFAT3) in tissue microarray containing 159 tumor tissues of non-small cell lung cancer. Results The positive rate of COX-2 expression was 42.8%, and the expression of COX-2 was significantly higher in squamous cell carcinoma than that in adenocarcinoma (52.9% vs 31.3%, χ2=7.723, P=0.005). The expression of COX-2 was significantly associated with differentiation grade, with the lower level in the poorer differentiation grade group (χ2=7.600, P=0.022). In this panel of samples, the expression of COX-2 was significantly correlated with c-Fos expression (r=0.456, P < 0.001) and NFAT3 level (r=0.294, P < 0.001). The correlation between the expressions of NFAT3 and c-Fos were also observed (r=0.231, P=0.003). Conclusion The expression of COX-2 was significantly associated with the expressions of transcription factors NFAT3 and c-Fos in nonsmall cell lung cancer. |
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| ISSN: | 1009-3419 1999-6187 |