A study on Beijing genotype in the clinical isolates of pulmonary drug-resistant tuberculosis
Background: Mycobacterium tuberculosis (MTB) Beijing strains are spread worldwide and are responsible for major outbreaks of tuberculosis (TB), sometimes spreading multidrug resistance (MDR). Aim: The aim of this study was to explore clinical features associated with the infection with Beijing strai...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Lung India |
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| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2017;volume=34;issue=5;spage=430;epage=433;aulast=Kumar |
| _version_ | 1819019072504856576 |
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| author | Ankit Kumar Ajay Kumar Verma Surya Kant Ved Prakash Anand Srivastava Kanchan Srivastava Amita Jain Kishore K Srivastava |
| author_facet | Ankit Kumar Ajay Kumar Verma Surya Kant Ved Prakash Anand Srivastava Kanchan Srivastava Amita Jain Kishore K Srivastava |
| author_sort | Ankit Kumar |
| collection | DOAJ |
| description | Background: Mycobacterium tuberculosis (MTB) Beijing strains are spread worldwide and are responsible for major outbreaks of tuberculosis (TB), sometimes spreading multidrug resistance (MDR). Aim: The aim of this study was to explore clinical features associated with the infection with Beijing strains among MDR patients of pulmonary TB in Lucknow and surrounding areas. Materials and Methods: It was a hospital-based epidemiological study. Our study population was selected from all the newly diagnosed patients attending outpatient department and admitted patients of Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India. Those isolates which were characterized to be MTB by morphological and molecular techniques were tested for their resistance against the first-line drugs; after which each patient's isolate was genotyped. Results: The results suggested that the presence of Beijing genotype in 31.78% of strains. Conclusion: Our results predicted that genotypic patterns reveal a large diversity among the MTB Beijing strain population. Increasing frequency of Beijing strains demands further research to unravel the factors behind its propensity to prevail. |
| first_indexed | 2024-12-21T03:29:30Z |
| format | Article |
| id | doaj.art-82263cdda8314c7fb03efe5919368ecf |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-12-21T03:29:30Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-82263cdda8314c7fb03efe5919368ecf2022-12-21T19:17:30ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2017-01-0134543043310.4103/lungindia.lungindia_451_16A study on Beijing genotype in the clinical isolates of pulmonary drug-resistant tuberculosisAnkit KumarAjay Kumar VermaSurya KantVed PrakashAnand SrivastavaKanchan SrivastavaAmita JainKishore K SrivastavaBackground: Mycobacterium tuberculosis (MTB) Beijing strains are spread worldwide and are responsible for major outbreaks of tuberculosis (TB), sometimes spreading multidrug resistance (MDR). Aim: The aim of this study was to explore clinical features associated with the infection with Beijing strains among MDR patients of pulmonary TB in Lucknow and surrounding areas. Materials and Methods: It was a hospital-based epidemiological study. Our study population was selected from all the newly diagnosed patients attending outpatient department and admitted patients of Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India. Those isolates which were characterized to be MTB by morphological and molecular techniques were tested for their resistance against the first-line drugs; after which each patient's isolate was genotyped. Results: The results suggested that the presence of Beijing genotype in 31.78% of strains. Conclusion: Our results predicted that genotypic patterns reveal a large diversity among the MTB Beijing strain population. Increasing frequency of Beijing strains demands further research to unravel the factors behind its propensity to prevail.http://www.lungindia.com/article.asp?issn=0970-2113;year=2017;volume=34;issue=5;spage=430;epage=433;aulast=KumarBeijing strainsgenotypingmultidrug resistancepolymerase chain reaction |
| spellingShingle | Ankit Kumar Ajay Kumar Verma Surya Kant Ved Prakash Anand Srivastava Kanchan Srivastava Amita Jain Kishore K Srivastava A study on Beijing genotype in the clinical isolates of pulmonary drug-resistant tuberculosis Lung India Beijing strains genotyping multidrug resistance polymerase chain reaction |
| title | A study on Beijing genotype in the clinical isolates of pulmonary drug-resistant tuberculosis |
| title_full | A study on Beijing genotype in the clinical isolates of pulmonary drug-resistant tuberculosis |
| title_fullStr | A study on Beijing genotype in the clinical isolates of pulmonary drug-resistant tuberculosis |
| title_full_unstemmed | A study on Beijing genotype in the clinical isolates of pulmonary drug-resistant tuberculosis |
| title_short | A study on Beijing genotype in the clinical isolates of pulmonary drug-resistant tuberculosis |
| title_sort | study on beijing genotype in the clinical isolates of pulmonary drug resistant tuberculosis |
| topic | Beijing strains genotyping multidrug resistance polymerase chain reaction |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2017;volume=34;issue=5;spage=430;epage=433;aulast=Kumar |
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