The Influence of the Gut Microbiome in Paediatric Cancer Origin and Treatment
Knowledge of the complexity of the gut microbiota is expanding, and its importance in physiological processes and disease development is widely studied. The aim of this review is to present the most relevant and recent research on the associations between gut microbiota and oncologic disease. Recent...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/11/1521 |
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| author | Viktória Sági Nóra Makra Noémi Csoszánszki Abel Decmann Dóra Szabó Miklós Garami |
| author_facet | Viktória Sági Nóra Makra Noémi Csoszánszki Abel Decmann Dóra Szabó Miklós Garami |
| author_sort | Viktória Sági |
| collection | DOAJ |
| description | Knowledge of the complexity of the gut microbiota is expanding, and its importance in physiological processes and disease development is widely studied. The aim of this review is to present the most relevant and recent research on the associations between gut microbiota and oncologic disease. Recently, a number of associations between the gut microbiome and neoplasms—regarding tumorigenesis, prognosis and therapeutic efficacy—have been reported. The effects of the gut microbiome on these processes are via the direct and indirect immunomodulating effects of bacteria. Studies have been done mainly in adult populations, where its effect on immunomodulating therapies was unambiguous. In paediatric populations, however, due to the low number of cases and the complex therapeutic approaches, there have been only a few studies. Among them, children with acute lymphoblastic leukaemia were mainly involved. Significant alterations in the abundance of certain bacteria were associated with altered therapeutic responses. Regarding solid tumours, studies with low case numbers have been reported; no significant discoveries have been described so far. In the future, studies with larger cohorts are needed in order to better understand the associations between bacteria and neoplasms and to improve prognosis in the paediatric oncologic population. |
| first_indexed | 2024-03-09T19:20:12Z |
| format | Article |
| id | doaj.art-8226c6a5a68b44bf8f0682eed78427bc |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T19:20:12Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-8226c6a5a68b44bf8f0682eed78427bc2023-11-24T03:27:45ZengMDPI AGAntibiotics2079-63822022-11-011111152110.3390/antibiotics11111521The Influence of the Gut Microbiome in Paediatric Cancer Origin and TreatmentViktória Sági0Nóra Makra1Noémi Csoszánszki2Abel Decmann3Dóra Szabó4Miklós Garami52nd Department of Pediatrics, Faculty of Medicine, Semmelweis University, 7-9 Tűzoltó Str., 1094 Budapest, HungaryInstitute of Medical Microbiology, Faculty of Medicine, Semmelweis University, 4 Nagyvárad tér, 1089 Budapest, Hungary2nd Department of Pediatrics, Faculty of Medicine, Semmelweis University, 7-9 Tűzoltó Str., 1094 Budapest, HungaryDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, 2a Korányi S. Str., 1083 Budapest, HungaryInstitute of Medical Microbiology, Faculty of Medicine, Semmelweis University, 4 Nagyvárad tér, 1089 Budapest, Hungary2nd Department of Pediatrics, Faculty of Medicine, Semmelweis University, 7-9 Tűzoltó Str., 1094 Budapest, HungaryKnowledge of the complexity of the gut microbiota is expanding, and its importance in physiological processes and disease development is widely studied. The aim of this review is to present the most relevant and recent research on the associations between gut microbiota and oncologic disease. Recently, a number of associations between the gut microbiome and neoplasms—regarding tumorigenesis, prognosis and therapeutic efficacy—have been reported. The effects of the gut microbiome on these processes are via the direct and indirect immunomodulating effects of bacteria. Studies have been done mainly in adult populations, where its effect on immunomodulating therapies was unambiguous. In paediatric populations, however, due to the low number of cases and the complex therapeutic approaches, there have been only a few studies. Among them, children with acute lymphoblastic leukaemia were mainly involved. Significant alterations in the abundance of certain bacteria were associated with altered therapeutic responses. Regarding solid tumours, studies with low case numbers have been reported; no significant discoveries have been described so far. In the future, studies with larger cohorts are needed in order to better understand the associations between bacteria and neoplasms and to improve prognosis in the paediatric oncologic population.https://www.mdpi.com/2079-6382/11/11/1521paediatriconcologygut microbiomechemotherapydysbiosis |
| spellingShingle | Viktória Sági Nóra Makra Noémi Csoszánszki Abel Decmann Dóra Szabó Miklós Garami The Influence of the Gut Microbiome in Paediatric Cancer Origin and Treatment Antibiotics paediatric oncology gut microbiome chemotherapy dysbiosis |
| title | The Influence of the Gut Microbiome in Paediatric Cancer Origin and Treatment |
| title_full | The Influence of the Gut Microbiome in Paediatric Cancer Origin and Treatment |
| title_fullStr | The Influence of the Gut Microbiome in Paediatric Cancer Origin and Treatment |
| title_full_unstemmed | The Influence of the Gut Microbiome in Paediatric Cancer Origin and Treatment |
| title_short | The Influence of the Gut Microbiome in Paediatric Cancer Origin and Treatment |
| title_sort | influence of the gut microbiome in paediatric cancer origin and treatment |
| topic | paediatric oncology gut microbiome chemotherapy dysbiosis |
| url | https://www.mdpi.com/2079-6382/11/11/1521 |
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