NLRP3 inflammasome as a novel therapeutic target for heart failure
Heart failure (HF) is a leading cause of mortality worldwide. The pathogenesis of HF is complex and has not yet been fully elucidated, which has slowed drug development and long-term treatments. Inflammasome-mediated responses occur during the progression of HF. It has been reported that energy meta...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2022-01-01
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| Series: | Anatolian Journal of Cardiology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-13103 |
| _version_ | 1797634228342489088 |
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| author | Shuangcui Wang Jiaqi Zhang Yuli Wang Xijuan Jiang Maojuan Guo Zhen Yang |
| author_facet | Shuangcui Wang Jiaqi Zhang Yuli Wang Xijuan Jiang Maojuan Guo Zhen Yang |
| author_sort | Shuangcui Wang |
| collection | DOAJ |
| description | Heart failure (HF) is a leading cause of mortality worldwide. The pathogenesis of HF is complex and has not yet been fully elucidated, which has slowed drug development and long-term treatments. Inflammasome-mediated responses occur during the progression of HF. It has been reported that energy metabolism and metabolites of intestinal flora are also involved in the process of HF, and they interact with each other to promote the progression of HF. NLR family pyrin domain containing 3 (NLRP3) inflammasome may be a key target in the relationship between inflammation-mediated energy metabolism and metabolites of intestinal flora. Elucidating the relationship among the above three factors may help to identify new molecular targets for the prevention and treatment of HF and ultimately affect the course of HF. In this study, we systematically summarize evidence regarding the relationship among NLRP3 inflammasome, energy metabolism, intestinal microflora metabolites, and inflammation, as well as highlight advantages of NLRP3 inflammasome in treating HF. |
| first_indexed | 2024-03-11T12:04:51Z |
| format | Article |
| id | doaj.art-8226ff9b5a734c4cad25c9a5a99fd568 |
| institution | Directory Open Access Journal |
| issn | 2149-2271 |
| language | English |
| last_indexed | 2024-03-11T12:04:51Z |
| publishDate | 2022-01-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Anatolian Journal of Cardiology |
| spelling | doaj.art-8226ff9b5a734c4cad25c9a5a99fd5682023-11-07T17:03:33ZengKARE PublishingAnatolian Journal of Cardiology2149-22712022-01-01261152210.5152/AnatolJCardiol.2021.580AJC-13103NLRP3 inflammasome as a novel therapeutic target for heart failureShuangcui Wang0Jiaqi Zhang1Yuli Wang2Xijuan Jiang3Maojuan Guo4Zhen Yang5Department of Integrative Medicine, Tianjin University of Traditional Chinese Medicine; Tianjin-ChinaDepartment of Integrative Medicine, Tianjin University of Traditional Chinese Medicine; Tianjin-ChinaDepartment of Integrative Medicine, Tianjin University of Traditional Chinese Medicine; Tianjin-ChinaDepartment of Integrative Medicine, Tianjin University of Traditional Chinese Medicine; Tianjin-ChinaDepartment of Integrative Medicine, Tianjin University of Traditional Chinese Medicine; Tianjin-ChinaDepartment of Chinese Medicine, Tianjin University of Traditional Chinese Medicine; Tianjin-ChinaHeart failure (HF) is a leading cause of mortality worldwide. The pathogenesis of HF is complex and has not yet been fully elucidated, which has slowed drug development and long-term treatments. Inflammasome-mediated responses occur during the progression of HF. It has been reported that energy metabolism and metabolites of intestinal flora are also involved in the process of HF, and they interact with each other to promote the progression of HF. NLR family pyrin domain containing 3 (NLRP3) inflammasome may be a key target in the relationship between inflammation-mediated energy metabolism and metabolites of intestinal flora. Elucidating the relationship among the above three factors may help to identify new molecular targets for the prevention and treatment of HF and ultimately affect the course of HF. In this study, we systematically summarize evidence regarding the relationship among NLRP3 inflammasome, energy metabolism, intestinal microflora metabolites, and inflammation, as well as highlight advantages of NLRP3 inflammasome in treating HF.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-13103heart failureinflammationnlrp3metabolismflora |
| spellingShingle | Shuangcui Wang Jiaqi Zhang Yuli Wang Xijuan Jiang Maojuan Guo Zhen Yang NLRP3 inflammasome as a novel therapeutic target for heart failure Anatolian Journal of Cardiology heart failure inflammation nlrp3 metabolism flora |
| title | NLRP3 inflammasome as a novel therapeutic target for heart failure |
| title_full | NLRP3 inflammasome as a novel therapeutic target for heart failure |
| title_fullStr | NLRP3 inflammasome as a novel therapeutic target for heart failure |
| title_full_unstemmed | NLRP3 inflammasome as a novel therapeutic target for heart failure |
| title_short | NLRP3 inflammasome as a novel therapeutic target for heart failure |
| title_sort | nlrp3 inflammasome as a novel therapeutic target for heart failure |
| topic | heart failure inflammation nlrp3 metabolism flora |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-13103 |
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