Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors
Cyanobacteria (blue-green microalgae) are ubiquitous, Gram-negative photoautotrophic prokaryotes. They are considered as one of the most efficient sources of bioactive secondary metabolites. More than 50% of cyanobacteria are cultivated on commercial platforms to extract bioactive compounds, which h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/1/247 |
| _version_ | 1797542258804785152 |
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| author | Hina Qamar Kashif Hussain Aishwarya Soni Anish Khan Touseef Hussain Benoît Chénais |
| author_facet | Hina Qamar Kashif Hussain Aishwarya Soni Anish Khan Touseef Hussain Benoît Chénais |
| author_sort | Hina Qamar |
| collection | DOAJ |
| description | Cyanobacteria (blue-green microalgae) are ubiquitous, Gram-negative photoautotrophic prokaryotes. They are considered as one of the most efficient sources of bioactive secondary metabolites. More than 50% of cyanobacteria are cultivated on commercial platforms to extract bioactive compounds, which have bene shown to possess anticancer activity. The chemically diverse natural compounds or their analogues induce cytotoxicity and potentially kill a variety of cancer cells via the induction of apoptosis, or altering the activation of cell signaling, involving especially the protein kinase-C family members, cell cycle arrest, mitochondrial dysfunctions and oxidative damage. These therapeutic properties enable their use in the pharma and healthcare sectors for the betterment of future generations. This review provides a baseline overview of the anti-cancerous cyanobacterial bioactive compounds, along with recently introduced nanomaterials that could be used for the development of new anticancer drugs to build a healthy future for mankind. |
| first_indexed | 2024-03-10T13:28:08Z |
| format | Article |
| id | doaj.art-8227d517969042aea187cd955273e51e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T13:28:08Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8227d517969042aea187cd955273e51e2023-11-21T08:34:28ZengMDPI AGMolecules1420-30492021-01-0126124710.3390/molecules26010247Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as NanovectorsHina Qamar0Kashif Hussain1Aishwarya Soni2Anish Khan3Touseef Hussain4Benoît Chénais5Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, IndiaPharmacy Section, Gyani Inder Singh Institute of Professional Studies, Dehradun 248003, IndiaDepartment of Biotechnology, Deenbandhu Chhotu Ram University of Science and Technology, Murthal, Sonepat 131039, IndiaCentre for Biotechnology, Maharshi Dayanand University, Rohtak 124001, IndiaDepartment of Botany, Aligarh Muslim University, Aligarh 202002, IndiaEA 2160 Mer Molécules Santé, Le Mans Université, F-72085 Le Mans, FranceCyanobacteria (blue-green microalgae) are ubiquitous, Gram-negative photoautotrophic prokaryotes. They are considered as one of the most efficient sources of bioactive secondary metabolites. More than 50% of cyanobacteria are cultivated on commercial platforms to extract bioactive compounds, which have bene shown to possess anticancer activity. The chemically diverse natural compounds or their analogues induce cytotoxicity and potentially kill a variety of cancer cells via the induction of apoptosis, or altering the activation of cell signaling, involving especially the protein kinase-C family members, cell cycle arrest, mitochondrial dysfunctions and oxidative damage. These therapeutic properties enable their use in the pharma and healthcare sectors for the betterment of future generations. This review provides a baseline overview of the anti-cancerous cyanobacterial bioactive compounds, along with recently introduced nanomaterials that could be used for the development of new anticancer drugs to build a healthy future for mankind.https://www.mdpi.com/1420-3049/26/1/247cyanobacteriabioactivitynatural compoundsanti-tumorcytotoxicitysecondary metabolites |
| spellingShingle | Hina Qamar Kashif Hussain Aishwarya Soni Anish Khan Touseef Hussain Benoît Chénais Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors Molecules cyanobacteria bioactivity natural compounds anti-tumor cytotoxicity secondary metabolites |
| title | Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors |
| title_full | Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors |
| title_fullStr | Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors |
| title_full_unstemmed | Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors |
| title_short | Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors |
| title_sort | cyanobacteria as natural therapeutics and pharmaceutical potential role in antitumor activity and as nanovectors |
| topic | cyanobacteria bioactivity natural compounds anti-tumor cytotoxicity secondary metabolites |
| url | https://www.mdpi.com/1420-3049/26/1/247 |
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