NRF2/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells

NRF2/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells

Abstract Glaucoma, the second leading cause of irreversible blindness worldwide, is associated with age and sensitivity to intraocular pressure (IOP). We have shown that elevated IOP causes an early increase in levels of reactive oxygen species (ROS) in the microbead occlusion mouse model. We also d...

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Bibliographic Details
Main Authors: Sarah Naguib, Jon R. Backstrom, Elisabeth Artis, Purnima Ghose, Amy Stahl, Rachael Hardin, Ameer A. Haider, John Ang, David J. Calkins, Tonia S. Rex
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Acta Neuropathologica Communications
Subjects:
glaucoma
Nrf2
Oxidative stress
Retinal ganglion cell
Optic nerve
Antioxidant
Online Access:https://doi.org/10.1186/s40478-023-01663-1

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