Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressings
Searching for an antibacterial and anti-inflammatory dressing that can stably adhere to wet tissues remains a momentous clinical challenge, especially in the context of treatment failure due to multi-drug-resistant bacteria. Using a hard template method in combination with an in situ chelating strat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Materials |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmats.2024.1379836/full |
| _version_ | 1797214825223290880 |
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| author | Wenxue Hou Wenxue Hou Zehui Lin Xiaomin Xia Xiaomin Xia Sa Sun Sa Sun Zhaojun Niu Zhaojun Niu Jie Liu Jie Liu Jiqing Lu Dongming Yin Xue Li Xue Li |
| author_facet | Wenxue Hou Wenxue Hou Zehui Lin Xiaomin Xia Xiaomin Xia Sa Sun Sa Sun Zhaojun Niu Zhaojun Niu Jie Liu Jie Liu Jiqing Lu Dongming Yin Xue Li Xue Li |
| author_sort | Wenxue Hou |
| collection | DOAJ |
| description | Searching for an antibacterial and anti-inflammatory dressing that can stably adhere to wet tissues remains a momentous clinical challenge, especially in the context of treatment failure due to multi-drug-resistant bacteria. Using a hard template method in combination with an in situ chelating strategy, three-dimensional nitrogen-doped graded porous carbon anchored 1.5–2.5 nm CeO2 quantum dots (CeO2-QDs) were tailor-designed in this study. Using the size effect, CeO2-QDs have a higher percentage of Ce3+ and oxygen vacancies that could amplify their antibacterial effects. Polyethyleneimine/polyacrylic acid (PEA) powder could self-gel and be adhesive due to its strong physical interactions, which make it an ideal carrier for CeO2-QDs. PEA@50 (mg/mL) CeO2-QDs hydrogel and PEA@75 (mg/mL) CeO2-QDs hydrogel with moderate doses of CeO2-QDs show a superior antibacterial effect against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) strains. Furthermore, PEA@50CeO2-QDs hydrogels possess excellent anti-inflammatory capacity through their antioxidant activity, which could promote macrophage M2 phenotype polarization. More importantly, cytotoxicity assays on L929 fibroblasts show that PEA@CeO2-QDs hydrogels have no significant toxicity, and a significant proliferative effect could be observed. Overall, PEA@50CeO2-QDs hydrogels have the potential to become a multifunctional wet tissue dressing with anti-inflammatory and antiseptic properties to promote the healing of infected wounds. |
| first_indexed | 2024-04-24T11:20:19Z |
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| id | doaj.art-82288114199c47e184a6d3ac69a60d6e |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-04-24T11:20:19Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-82288114199c47e184a6d3ac69a60d6e2024-04-11T04:47:14ZengFrontiers Media S.A.Frontiers in Materials2296-80162024-04-011110.3389/fmats.2024.13798361379836Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressingsWenxue Hou0Wenxue Hou1Zehui Lin2Xiaomin Xia3Xiaomin Xia4Sa Sun5Sa Sun6Zhaojun Niu7Zhaojun Niu8Jie Liu9Jie Liu10Jiqing Lu11Dongming Yin12Xue Li13Xue Li14Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaInstitute of Materials for Energy and Environment, College of Materials Science and Engineering, Qingdao University, Qingdao, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaKey Laboratory of the Ministry of Education for Advanced Catalysis Materials, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua, ChinaState Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, ChinaDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, ChinaSchool of Stomatology, Qingdao University, Qingdao, ChinaSearching for an antibacterial and anti-inflammatory dressing that can stably adhere to wet tissues remains a momentous clinical challenge, especially in the context of treatment failure due to multi-drug-resistant bacteria. Using a hard template method in combination with an in situ chelating strategy, three-dimensional nitrogen-doped graded porous carbon anchored 1.5–2.5 nm CeO2 quantum dots (CeO2-QDs) were tailor-designed in this study. Using the size effect, CeO2-QDs have a higher percentage of Ce3+ and oxygen vacancies that could amplify their antibacterial effects. Polyethyleneimine/polyacrylic acid (PEA) powder could self-gel and be adhesive due to its strong physical interactions, which make it an ideal carrier for CeO2-QDs. PEA@50 (mg/mL) CeO2-QDs hydrogel and PEA@75 (mg/mL) CeO2-QDs hydrogel with moderate doses of CeO2-QDs show a superior antibacterial effect against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) strains. Furthermore, PEA@50CeO2-QDs hydrogels possess excellent anti-inflammatory capacity through their antioxidant activity, which could promote macrophage M2 phenotype polarization. More importantly, cytotoxicity assays on L929 fibroblasts show that PEA@CeO2-QDs hydrogels have no significant toxicity, and a significant proliferative effect could be observed. Overall, PEA@50CeO2-QDs hydrogels have the potential to become a multifunctional wet tissue dressing with anti-inflammatory and antiseptic properties to promote the healing of infected wounds.https://www.frontiersin.org/articles/10.3389/fmats.2024.1379836/fullCeO2 quantum dotspolyethyleneimine/polyacrylic acid hydrogelantioxidationantimicrobialanti-inflammatory |
| spellingShingle | Wenxue Hou Wenxue Hou Zehui Lin Xiaomin Xia Xiaomin Xia Sa Sun Sa Sun Zhaojun Niu Zhaojun Niu Jie Liu Jie Liu Jiqing Lu Dongming Yin Xue Li Xue Li Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressings Frontiers in Materials CeO2 quantum dots polyethyleneimine/polyacrylic acid hydrogel antioxidation antimicrobial anti-inflammatory |
| title | Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressings |
| title_full | Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressings |
| title_fullStr | Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressings |
| title_full_unstemmed | Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressings |
| title_short | Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressings |
| title_sort | antibacterial and anti inflammatory polyethyleneimine polyacrylic acid hydrogel loaded with ceo2 quantum dots for wet tissue wound dressings |
| topic | CeO2 quantum dots polyethyleneimine/polyacrylic acid hydrogel antioxidation antimicrobial anti-inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fmats.2024.1379836/full |
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