MEG Node Degree for Focus Localization: Comparison with Invasive EEG
Epilepsy surgery is a viable therapy option for patients with pharmacoresistant focal epilepsies. A prerequisite for postoperative seizure freedom is the localization of the epileptogenic zone, e.g., using electro- and magnetoencephalography (EEG/MEG). Evidence shows that resting state MEG contains...
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MDPI AG
2023-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/438 |
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| author | Stefan Rampp Martin Kaltenhäuser Nadia Müller-Voggel Arnd Doerfler Burkhard S. Kasper Hajo M. Hamer Sebastian Brandner Michael Buchfelder |
| author_facet | Stefan Rampp Martin Kaltenhäuser Nadia Müller-Voggel Arnd Doerfler Burkhard S. Kasper Hajo M. Hamer Sebastian Brandner Michael Buchfelder |
| author_sort | Stefan Rampp |
| collection | DOAJ |
| description | Epilepsy surgery is a viable therapy option for patients with pharmacoresistant focal epilepsies. A prerequisite for postoperative seizure freedom is the localization of the epileptogenic zone, e.g., using electro- and magnetoencephalography (EEG/MEG). Evidence shows that resting state MEG contains subtle alterations, which may add information to the workup of epilepsy surgery. Here, we investigate node degree (ND), a graph-theoretical parameter of functional connectivity, in relation to the seizure onset zone (SOZ) determined by invasive EEG (iEEG) in a consecutive series of 50 adult patients. Resting state data were subjected to whole brain, all-to-all connectivity analysis using the imaginary part of coherence. Graphs were described using parcellated ND. SOZ localization was investigated on a lobar and sublobar level. On a lobar level, all frequency bands except alpha showed significantly higher maximal ND (mND) values inside the SOZ compared to outside (ratios 1.11–1.20, alpha 1.02). Area-under-the-curve (AUC) was 0.67–0.78 for all expected alpha (0.44, ns). On a sublobar level, mND inside the SOZ was higher for all frequency bands (1.13–1.38, AUC 0.58–0.78) except gamma (1.02). MEG ND is significantly related to SOZ in delta, theta and beta bands. ND may provide new localization tools for presurgical evaluation of epilepsy surgery. |
| first_indexed | 2024-03-11T09:07:02Z |
| format | Article |
| id | doaj.art-822bc8b83932471a9a0af52f58084867 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:07:02Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-822bc8b83932471a9a0af52f580848672023-11-16T19:18:14ZengMDPI AGBiomedicines2227-90592023-02-0111243810.3390/biomedicines11020438MEG Node Degree for Focus Localization: Comparison with Invasive EEGStefan Rampp0Martin Kaltenhäuser1Nadia Müller-Voggel2Arnd Doerfler3Burkhard S. Kasper4Hajo M. Hamer5Sebastian Brandner6Michael Buchfelder7Department of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neuroradiology, University Hospital Erlangen, 91054 Erlangen, GermanyEpilepsy Center, Department of Neurology, University Hospital Erlangen, 91054 Erlangen, GermanyEpilepsy Center, Department of Neurology, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyDepartment of Neurosurgery, University Hospital Erlangen, 91054 Erlangen, GermanyEpilepsy surgery is a viable therapy option for patients with pharmacoresistant focal epilepsies. A prerequisite for postoperative seizure freedom is the localization of the epileptogenic zone, e.g., using electro- and magnetoencephalography (EEG/MEG). Evidence shows that resting state MEG contains subtle alterations, which may add information to the workup of epilepsy surgery. Here, we investigate node degree (ND), a graph-theoretical parameter of functional connectivity, in relation to the seizure onset zone (SOZ) determined by invasive EEG (iEEG) in a consecutive series of 50 adult patients. Resting state data were subjected to whole brain, all-to-all connectivity analysis using the imaginary part of coherence. Graphs were described using parcellated ND. SOZ localization was investigated on a lobar and sublobar level. On a lobar level, all frequency bands except alpha showed significantly higher maximal ND (mND) values inside the SOZ compared to outside (ratios 1.11–1.20, alpha 1.02). Area-under-the-curve (AUC) was 0.67–0.78 for all expected alpha (0.44, ns). On a sublobar level, mND inside the SOZ was higher for all frequency bands (1.13–1.38, AUC 0.58–0.78) except gamma (1.02). MEG ND is significantly related to SOZ in delta, theta and beta bands. ND may provide new localization tools for presurgical evaluation of epilepsy surgery.https://www.mdpi.com/2227-9059/11/2/438MEGepilepsyepilepsy surgeryconnectivitygraph theoryfocus localization |
| spellingShingle | Stefan Rampp Martin Kaltenhäuser Nadia Müller-Voggel Arnd Doerfler Burkhard S. Kasper Hajo M. Hamer Sebastian Brandner Michael Buchfelder MEG Node Degree for Focus Localization: Comparison with Invasive EEG Biomedicines MEG epilepsy epilepsy surgery connectivity graph theory focus localization |
| title | MEG Node Degree for Focus Localization: Comparison with Invasive EEG |
| title_full | MEG Node Degree for Focus Localization: Comparison with Invasive EEG |
| title_fullStr | MEG Node Degree for Focus Localization: Comparison with Invasive EEG |
| title_full_unstemmed | MEG Node Degree for Focus Localization: Comparison with Invasive EEG |
| title_short | MEG Node Degree for Focus Localization: Comparison with Invasive EEG |
| title_sort | meg node degree for focus localization comparison with invasive eeg |
| topic | MEG epilepsy epilepsy surgery connectivity graph theory focus localization |
| url | https://www.mdpi.com/2227-9059/11/2/438 |
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