Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored
Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease, that includes Crohn’s disease (CD) and ulcerative colitis (UC), having progressively increasing global incidence. Disturbed intestinal flora has been highlighted as an important feature of IBD and offers promi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/13/11004 |
| _version_ | 1797591490884534272 |
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| author | Mengjie Zhu Yijie Song Yu Xu Hongxi Xu |
| author_facet | Mengjie Zhu Yijie Song Yu Xu Hongxi Xu |
| author_sort | Mengjie Zhu |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease, that includes Crohn’s disease (CD) and ulcerative colitis (UC), having progressively increasing global incidence. Disturbed intestinal flora has been highlighted as an important feature of IBD and offers promising strategies for IBD remedies. A brief overview of the variations occurring in intestinal flora during IBD is presented, and the role of the gut microbiota in intestinal barrier maintenance, immune and metabolic regulation, and the absorption and supply of nutrients is reviewed. More importantly, we review drug research on gut microbiota in the past ten years, including research on clinical and natural drugs, as well as adjuvant therapies, such as Fecal Microbiota Transplantation and probiotic supplements. We also summarize the interventions and mechanisms of these drugs on gut microbiota. |
| first_indexed | 2024-03-11T01:39:10Z |
| format | Article |
| id | doaj.art-822c925218b94a9bb086d5291d33156c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:39:10Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-822c925218b94a9bb086d5291d33156c2023-11-18T16:46:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124131100410.3390/ijms241311004Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions ExploredMengjie Zhu0Yijie Song1Yu Xu2Hongxi Xu3School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaInflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease, that includes Crohn’s disease (CD) and ulcerative colitis (UC), having progressively increasing global incidence. Disturbed intestinal flora has been highlighted as an important feature of IBD and offers promising strategies for IBD remedies. A brief overview of the variations occurring in intestinal flora during IBD is presented, and the role of the gut microbiota in intestinal barrier maintenance, immune and metabolic regulation, and the absorption and supply of nutrients is reviewed. More importantly, we review drug research on gut microbiota in the past ten years, including research on clinical and natural drugs, as well as adjuvant therapies, such as Fecal Microbiota Transplantation and probiotic supplements. We also summarize the interventions and mechanisms of these drugs on gut microbiota.https://www.mdpi.com/1422-0067/24/13/11004inflammatory bowel diseasegut microbiomeimmunitymetabolitessynthetic drugsnatural products |
| spellingShingle | Mengjie Zhu Yijie Song Yu Xu Hongxi Xu Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored International Journal of Molecular Sciences inflammatory bowel disease gut microbiome immunity metabolites synthetic drugs natural products |
| title | Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored |
| title_full | Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored |
| title_fullStr | Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored |
| title_full_unstemmed | Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored |
| title_short | Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored |
| title_sort | manipulating microbiota in inflammatory bowel disease treatment clinical and natural product interventions explored |
| topic | inflammatory bowel disease gut microbiome immunity metabolites synthetic drugs natural products |
| url | https://www.mdpi.com/1422-0067/24/13/11004 |
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