MMAB promotes negative feedback control of cholesterol homeostasis
The mechanisms governing cholesterol homeostasis remain incompletely understood. Here, the authors develop an integrative genomic strategy to identify MMAB, and enzyme in the adenosylcobalamin pathway, as a regulator of hepatic LDLR activity and cholesterol biosynthesis.
Bibliographic Details
| Main Authors: |
Leigh Goedeke,
Alberto Canfrán-Duque,
Noemi Rotllan,
Balkrishna Chaube,
Bonne M. Thompson,
Richard G. Lee,
Gary W. Cline,
Jeffrey G. McDonald,
Gerald I. Shulman,
Miguel A. Lasunción,
Yajaira Suárez,
Carlos Fernández-Hernando |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-26787-7
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