A tough and mechanically stable adhesive hydrogel for non-invasive wound repair
Wound healing has been a great challenge throughout human history. Improper treatment for wounds is so easy to lead to infection and a series of serious symptoms, even death. Because of the ability of absorbing fluid and keeping a moist environment, the hydrogel with 3D networks is ideal candidate f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1173247/full |
| _version_ | 1797847637127331840 |
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| author | Xiaochun Liu Si Qin Lei Xu Guo Fu Yongjun Huang Chaoqun Yu Guoyun Cheng Ying Li Yunzhi He Yong Qi Dawei Sun |
| author_facet | Xiaochun Liu Si Qin Lei Xu Guo Fu Yongjun Huang Chaoqun Yu Guoyun Cheng Ying Li Yunzhi He Yong Qi Dawei Sun |
| author_sort | Xiaochun Liu |
| collection | DOAJ |
| description | Wound healing has been a great challenge throughout human history. Improper treatment for wounds is so easy to lead to infection and a series of serious symptoms, even death. Because of the ability of absorbing fluid and keeping a moist environment, the hydrogel with 3D networks is ideal candidate for wound dressing. More important, it has good biocompatibility. However, most of the hydrogel dressings reported have weak mechanical properties and adhesion properties, which greatly limit their clinical application. Herein, a tough adhesive hydrogel with good mechanical stability for non-invasive wound repair is reported. The hydrogel is composed of polyethylene glycol dimethacrylate (PEGDA), chitosan (CS) and chitin nano-whisker (CW). PEGDA and CS form interpenetrating network hydrogel through free radical polymerization reaction under the UV light. The introduction of CW further enhances the toughness of the hydrogel. The pH-sensitive CS can form adhesion to various materials through topological adhesion. As a wound closure repair material, PEGDA/CS/CW hydrogel not only has the characteristic of effectively closing the wound, defending against invading bacteria, and keeping the wound clean, but also has good tensile and mechanical stability, which is expected to realize the closure and repair of joints and other moving parts of the wound. This adhesive hydrogel is proven a promising material for wound closure repair. |
| first_indexed | 2024-04-09T18:14:39Z |
| format | Article |
| id | doaj.art-8230c07bb24c4f8cab351c9110cb5150 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-09T18:14:39Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-8230c07bb24c4f8cab351c9110cb51502023-04-13T05:00:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-04-011110.3389/fbioe.2023.11732471173247A tough and mechanically stable adhesive hydrogel for non-invasive wound repairXiaochun Liu0Si Qin1Lei Xu2Guo Fu3Yongjun Huang4Chaoqun Yu5Guoyun Cheng6Ying Li7Yunzhi He8Yong Qi9Dawei Sun10Department of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Orthopedics, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, ChinaWound healing has been a great challenge throughout human history. Improper treatment for wounds is so easy to lead to infection and a series of serious symptoms, even death. Because of the ability of absorbing fluid and keeping a moist environment, the hydrogel with 3D networks is ideal candidate for wound dressing. More important, it has good biocompatibility. However, most of the hydrogel dressings reported have weak mechanical properties and adhesion properties, which greatly limit their clinical application. Herein, a tough adhesive hydrogel with good mechanical stability for non-invasive wound repair is reported. The hydrogel is composed of polyethylene glycol dimethacrylate (PEGDA), chitosan (CS) and chitin nano-whisker (CW). PEGDA and CS form interpenetrating network hydrogel through free radical polymerization reaction under the UV light. The introduction of CW further enhances the toughness of the hydrogel. The pH-sensitive CS can form adhesion to various materials through topological adhesion. As a wound closure repair material, PEGDA/CS/CW hydrogel not only has the characteristic of effectively closing the wound, defending against invading bacteria, and keeping the wound clean, but also has good tensile and mechanical stability, which is expected to realize the closure and repair of joints and other moving parts of the wound. This adhesive hydrogel is proven a promising material for wound closure repair.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1173247/fulladhesive hydrogeltopological adhesionwound repairtoughnessmechanical stability |
| spellingShingle | Xiaochun Liu Si Qin Lei Xu Guo Fu Yongjun Huang Chaoqun Yu Guoyun Cheng Ying Li Yunzhi He Yong Qi Dawei Sun A tough and mechanically stable adhesive hydrogel for non-invasive wound repair Frontiers in Bioengineering and Biotechnology adhesive hydrogel topological adhesion wound repair toughness mechanical stability |
| title | A tough and mechanically stable adhesive hydrogel for non-invasive wound repair |
| title_full | A tough and mechanically stable adhesive hydrogel for non-invasive wound repair |
| title_fullStr | A tough and mechanically stable adhesive hydrogel for non-invasive wound repair |
| title_full_unstemmed | A tough and mechanically stable adhesive hydrogel for non-invasive wound repair |
| title_short | A tough and mechanically stable adhesive hydrogel for non-invasive wound repair |
| title_sort | tough and mechanically stable adhesive hydrogel for non invasive wound repair |
| topic | adhesive hydrogel topological adhesion wound repair toughness mechanical stability |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1173247/full |
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