Terpene Glycosides from the Roots of <em>Sanguisorba officinalis</em> L. and Their Hemostatic Activities
Guided by a hemostasis bioassay, seven terpene glycosides were isolated from the roots of <em>Sanguisorba officinalis</em> L. by silica gel column chromatography and preparative HPLC. On the grounds of chemical and spectroscopic methods, their structures were identified a...
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| Format: | Article |
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MDPI AG
2012-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/7/7629 |
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| author | Wei Sun Zi-Long Zhang Xin Liu Shuang Zhang Lu He Zhe Wang Guang-Shu Wang |
| author_facet | Wei Sun Zi-Long Zhang Xin Liu Shuang Zhang Lu He Zhe Wang Guang-Shu Wang |
| author_sort | Wei Sun |
| collection | DOAJ |
| description | Guided by a hemostasis bioassay, seven terpene glycosides were isolated from the roots of <em>Sanguisorba officinalis</em> L. by silica gel column chromatography and preparative HPLC. On the grounds of chemical and spectroscopic methods, their structures were identified as citronellol-1-<em>O</em>-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (<strong>1</strong>), geraniol-1-<em>O</em>-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (<strong>2</strong>), geraniol-1-<em>O</em>-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside (<strong>3</strong>), 3β-[(α-l-arabinopyranosyl)oxy]-19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (<strong>4</strong>), 3β-[(α-l-arabinopyranosyl)-oxy]-19α-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (ziyu-glycoside I,<strong> 5</strong>), 3β,19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (<strong>6</strong>) and 3β,19α-di-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (<strong>7</strong>). Compound <strong>1</strong> is a new mono-terpene glycoside and compounds <strong>2</strong>, <strong>3</strong><strong> </strong>and <strong>5</strong> were isolated from the <em>Sanguisorba</em> genus for the first time. Compounds <strong>1</strong>–<strong>7</strong> were assayed for their hemostatic activities with a Goat Anti-Human α2-plasmin inhibitor ELISA kit, and ziyu-glycoside I (<strong>5</strong>) showed the strongest hemostatic activity among the seven terpene glycosides. This is the first report that ziyu-glycoside Ι has strong hemostatic activity. |
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| id | doaj.art-8231c6b735be41b88ae7cdf852f53d70 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
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| spelling | doaj.art-8231c6b735be41b88ae7cdf852f53d702022-12-22T03:58:22ZengMDPI AGMolecules1420-30492012-06-011777629763610.3390/molecules17077629Terpene Glycosides from the Roots of <em>Sanguisorba officinalis</em> L. and Their Hemostatic ActivitiesWei SunZi-Long ZhangXin LiuShuang ZhangLu HeZhe WangGuang-Shu WangGuided by a hemostasis bioassay, seven terpene glycosides were isolated from the roots of <em>Sanguisorba officinalis</em> L. by silica gel column chromatography and preparative HPLC. On the grounds of chemical and spectroscopic methods, their structures were identified as citronellol-1-<em>O</em>-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (<strong>1</strong>), geraniol-1-<em>O</em>-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (<strong>2</strong>), geraniol-1-<em>O</em>-α-l-arabinopyranosyl-(1→6)-β-d-glucopyranoside (<strong>3</strong>), 3β-[(α-l-arabinopyranosyl)oxy]-19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (<strong>4</strong>), 3β-[(α-l-arabinopyranosyl)-oxy]-19α-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (ziyu-glycoside I,<strong> 5</strong>), 3β,19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (<strong>6</strong>) and 3β,19α-di-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (<strong>7</strong>). Compound <strong>1</strong> is a new mono-terpene glycoside and compounds <strong>2</strong>, <strong>3</strong><strong> </strong>and <strong>5</strong> were isolated from the <em>Sanguisorba</em> genus for the first time. Compounds <strong>1</strong>–<strong>7</strong> were assayed for their hemostatic activities with a Goat Anti-Human α2-plasmin inhibitor ELISA kit, and ziyu-glycoside I (<strong>5</strong>) showed the strongest hemostatic activity among the seven terpene glycosides. This is the first report that ziyu-glycoside Ι has strong hemostatic activity.http://www.mdpi.com/1420-3049/17/7/7629<em>Sanguisorba officinalis</em>ziyu-glycoside Ιcitronellolgeraniolhemostasis |
| spellingShingle | Wei Sun Zi-Long Zhang Xin Liu Shuang Zhang Lu He Zhe Wang Guang-Shu Wang Terpene Glycosides from the Roots of <em>Sanguisorba officinalis</em> L. and Their Hemostatic Activities Molecules <em>Sanguisorba officinalis</em> ziyu-glycoside Ι citronellol geraniol hemostasis |
| title | Terpene Glycosides from the Roots of <em>Sanguisorba officinalis</em> L. and Their Hemostatic Activities |
| title_full | Terpene Glycosides from the Roots of <em>Sanguisorba officinalis</em> L. and Their Hemostatic Activities |
| title_fullStr | Terpene Glycosides from the Roots of <em>Sanguisorba officinalis</em> L. and Their Hemostatic Activities |
| title_full_unstemmed | Terpene Glycosides from the Roots of <em>Sanguisorba officinalis</em> L. and Their Hemostatic Activities |
| title_short | Terpene Glycosides from the Roots of <em>Sanguisorba officinalis</em> L. and Their Hemostatic Activities |
| title_sort | terpene glycosides from the roots of lt em gt sanguisorba officinalis lt em gt l and their hemostatic activities |
| topic | <em>Sanguisorba officinalis</em> ziyu-glycoside Ι citronellol geraniol hemostasis |
| url | http://www.mdpi.com/1420-3049/17/7/7629 |
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