Mid‐life and late‐life vascular risk factor burden and neuropathology in old age
Abstract Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. Methods We studied participants from the Framingham Heart Study who participated in our voluntary brain bank pro...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-12-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.50936 |
| _version_ | 1819118813064462336 |
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| author | Sarah C. Conner Matthew P. Pase Herman Carneiro Mekala R. Raman Ann C. McKee Victor E. Alvarez Jamie M. Walker Claudia L. Satizabal Jayandra J. Himali Thor D. Stein Alexa Beiser Sudha Seshadri |
| author_facet | Sarah C. Conner Matthew P. Pase Herman Carneiro Mekala R. Raman Ann C. McKee Victor E. Alvarez Jamie M. Walker Claudia L. Satizabal Jayandra J. Himali Thor D. Stein Alexa Beiser Sudha Seshadri |
| author_sort | Sarah C. Conner |
| collection | DOAJ |
| description | Abstract Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. Methods We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid‐life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi‐quantitatively assessed by board‐certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer’s disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid‐life and before death) and neuropathological outcomes using logistic and proportional‐odds logistic models. Results The median time interval between FSRP and death was 33.4 years for mid‐life FSRP and 4.4 years for final FSRP measurement before death. Higher mid‐life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late‐life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid‐life vascular risk burden was not associated with Alzheimer’s disease pathology, though late‐life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]). Interpretation Mid‐life vascular risk burden was predictive of cerebrovascular but not Alzheimer’s disease neuropathology, even after adjustment for vascular risk factors before death. |
| first_indexed | 2024-12-22T05:54:50Z |
| format | Article |
| id | doaj.art-82320af58984449f8dba3f30cff9e694 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-22T05:54:50Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-82320af58984449f8dba3f30cff9e6942022-12-21T18:36:45ZengWileyAnnals of Clinical and Translational Neurology2328-95032019-12-016122403241210.1002/acn3.50936Mid‐life and late‐life vascular risk factor burden and neuropathology in old ageSarah C. Conner0Matthew P. Pase1Herman Carneiro2Mekala R. Raman3Ann C. McKee4Victor E. Alvarez5Jamie M. Walker6Claudia L. Satizabal7Jayandra J. Himali8Thor D. Stein9Alexa Beiser10Sudha Seshadri11Framingham Heart Study Framingham MassachusettsFramingham Heart Study Framingham MassachusettsFramingham Heart Study Framingham MassachusettsDepartment of Neurology Boston University School of Medicine Boston MassachusettsDepartment of Neurology Boston University School of Medicine Boston MassachusettsBoston University Alzheimer's Disease and CTE Center Boston University School of Medicine Boston MassachusettsGlenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases UT Health San Antonio San Antonio TexasFramingham Heart Study Framingham MassachusettsFramingham Heart Study Framingham MassachusettsBoston University Alzheimer's Disease and CTE Center Boston University School of Medicine Boston MassachusettsFramingham Heart Study Framingham MassachusettsFramingham Heart Study Framingham MassachusettsAbstract Objective To determine whether vascular risk factor burden in mid‐ or late‐life associates with postmortem vascular and neurodegenerative pathologies in a community‐based sample. Methods We studied participants from the Framingham Heart Study who participated in our voluntary brain bank program. Overall vascular risk factor burden was calculated using the Framingham Stroke Risk Profile (FSRP). Mid‐life FSRP was measured at 50 to 60 years of age. Following death, brains were autopsied and semi‐quantitatively assessed by board‐certified neuropathologists for cerebrovascular outcomes (cortical infarcts, subcortical infarcts, atherosclerosis, arteriosclerosis) and Alzheimer’s disease pathology (Braak stage, cerebral amyloid angiopathy, and neuritic plaque score). We estimated adjusted odds ratios between vascular risk burden (at mid‐life and before death) and neuropathological outcomes using logistic and proportional‐odds logistic models. Results The median time interval between FSRP and death was 33.4 years for mid‐life FSRP and 4.4 years for final FSRP measurement before death. Higher mid‐life vascular risk burden was associated with increased odds of all cerebrovascular pathology, even with adjustment for vascular risk burden before death. Late‐life vascular risk burden was associated with increased odds of cortical infarcts (OR [95% CI]: 1.04 [1.00, 1.08]) and arteriosclerosis stage (OR [95% CI]: 1.03 [1.00, 1.05]). Mid‐life vascular risk burden was not associated with Alzheimer’s disease pathology, though late‐life vascular risk burden was associated with increased odds of higher Braak stage (OR [95% CI]: 1.03 [1.01, 1.05]). Interpretation Mid‐life vascular risk burden was predictive of cerebrovascular but not Alzheimer’s disease neuropathology, even after adjustment for vascular risk factors before death.https://doi.org/10.1002/acn3.50936 |
| spellingShingle | Sarah C. Conner Matthew P. Pase Herman Carneiro Mekala R. Raman Ann C. McKee Victor E. Alvarez Jamie M. Walker Claudia L. Satizabal Jayandra J. Himali Thor D. Stein Alexa Beiser Sudha Seshadri Mid‐life and late‐life vascular risk factor burden and neuropathology in old age Annals of Clinical and Translational Neurology |
| title | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
| title_full | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
| title_fullStr | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
| title_full_unstemmed | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
| title_short | Mid‐life and late‐life vascular risk factor burden and neuropathology in old age |
| title_sort | mid life and late life vascular risk factor burden and neuropathology in old age |
| url | https://doi.org/10.1002/acn3.50936 |
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