Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
MiR-122 levels correlate with metastasis in human liver cancer but not in mouse models. Here the authors show that miR-122 targets TGFßR1 in mice but TGFß1 in humans, that swapping this specificity affects metastasis, and that many other receptor-ligand pairs are differentially targeted by miRNAs ac...
Main Authors: | Shenyi Yin, Yu Fan, Hanshuo Zhang, Zhihua Zhao, Yang Hao, Juan Li, Changhong Sun, Junyu Yang, Zhenjun Yang, Xiao Yang, Jian Lu, Jianzhong Jeff Xi |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2016-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms11012 |
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