Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.

Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.

Ischemic and traumatic brain injury is associated with increased risk for death and disability. The inhibition of penumbral tissue damage has been recognized as a target for therapeutic intervention, because cellular injury evolves progressively upon ATP-depletion and loss of ion homeostasis. In pat...

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Bibliographic Details
Main Authors: Christian I Schwer, Cornelius Lehane, Timo Guelzow, Simone Zenker, Karl M Strosing, Sashko Spassov, Anika Erxleben, Bernd Heimrich, Hartmut Buerkle, Matjaz Humar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3805597?pdf=render

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