Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin
Polyphenols are considered popular ingredients in the pharmaceutical and medical fields due to their preventive and therapeutic properties. However, the potential effects and mechanisms of action of individual polyphenols remain largely unknown. Herein, we analyzed recent data on the synthetic pathw...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/22/14413 |
| _version_ | 1797465036669583360 |
|---|---|
| author | Aseel Ali Hasan Victor Tatarskiy Elena Kalinina |
| author_facet | Aseel Ali Hasan Victor Tatarskiy Elena Kalinina |
| author_sort | Aseel Ali Hasan |
| collection | DOAJ |
| description | Polyphenols are considered popular ingredients in the pharmaceutical and medical fields due to their preventive and therapeutic properties. However, the potential effects and mechanisms of action of individual polyphenols remain largely unknown. Herein, we analyzed recent data on the synthetic pathways, features, and similarity of the properties of quercetin, as the most famous flavonoid, and curcumin, a representative of curcuminoids that despite their anti-oxidant activity, also have a pro-oxidant effect, depending on the concentration and the cellular environment. This review focuses on an analysis of their anti-cancer efficacy against various cancer cell lines via cell cycle arrest (regulation of p53/p21 and CDK/cyclins) and by triggering the mitochondrial intrinsic (Bcl-2/Bax/caspase 9) apoptotic pathway, as well as through the modulation of the signaling pathways (PI3K/Akt, Wnt/β-catenin, JAK/STAT, MAPK, p53, and NF-ĸB) and their influence on the non-coding RNAs involved in angiogenesis, invasion, migration, and metastasis. The therapeutic potential of quercetin and curcumin is discussed not only on the basis of their anti-cancer effects, but also with regard to their anti-diabetic, anti-obesity, anti-inflammatory, and anti-bacterial actions. |
| first_indexed | 2024-03-09T18:15:49Z |
| format | Article |
| id | doaj.art-8234df3296c24a2eb5b7b8b66c0625c6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:15:49Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8234df3296c24a2eb5b7b8b66c0625c62023-11-24T08:43:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221441310.3390/ijms232214413Synthetic Pathways and the Therapeutic Potential of Quercetin and CurcuminAseel Ali Hasan0Victor Tatarskiy1Elena Kalinina2T.T. Berezov Department of Biochemistry, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, RussiaLaboratory of Molecular Oncobiology, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, RussiaT.T. Berezov Department of Biochemistry, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, RussiaPolyphenols are considered popular ingredients in the pharmaceutical and medical fields due to their preventive and therapeutic properties. However, the potential effects and mechanisms of action of individual polyphenols remain largely unknown. Herein, we analyzed recent data on the synthetic pathways, features, and similarity of the properties of quercetin, as the most famous flavonoid, and curcumin, a representative of curcuminoids that despite their anti-oxidant activity, also have a pro-oxidant effect, depending on the concentration and the cellular environment. This review focuses on an analysis of their anti-cancer efficacy against various cancer cell lines via cell cycle arrest (regulation of p53/p21 and CDK/cyclins) and by triggering the mitochondrial intrinsic (Bcl-2/Bax/caspase 9) apoptotic pathway, as well as through the modulation of the signaling pathways (PI3K/Akt, Wnt/β-catenin, JAK/STAT, MAPK, p53, and NF-ĸB) and their influence on the non-coding RNAs involved in angiogenesis, invasion, migration, and metastasis. The therapeutic potential of quercetin and curcumin is discussed not only on the basis of their anti-cancer effects, but also with regard to their anti-diabetic, anti-obesity, anti-inflammatory, and anti-bacterial actions.https://www.mdpi.com/1422-0067/23/22/14413polyphenolsquercetincurcuminanti-oxidant and pro-oxidant effectsanti-cancer treatment |
| spellingShingle | Aseel Ali Hasan Victor Tatarskiy Elena Kalinina Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin International Journal of Molecular Sciences polyphenols quercetin curcumin anti-oxidant and pro-oxidant effects anti-cancer treatment |
| title | Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin |
| title_full | Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin |
| title_fullStr | Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin |
| title_full_unstemmed | Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin |
| title_short | Synthetic Pathways and the Therapeutic Potential of Quercetin and Curcumin |
| title_sort | synthetic pathways and the therapeutic potential of quercetin and curcumin |
| topic | polyphenols quercetin curcumin anti-oxidant and pro-oxidant effects anti-cancer treatment |
| url | https://www.mdpi.com/1422-0067/23/22/14413 |
| work_keys_str_mv | AT aseelalihasan syntheticpathwaysandthetherapeuticpotentialofquercetinandcurcumin AT victortatarskiy syntheticpathwaysandthetherapeuticpotentialofquercetinandcurcumin AT elenakalinina syntheticpathwaysandthetherapeuticpotentialofquercetinandcurcumin |