Determining cellular CTCF and cohesin abundances to constrain 3D genome models

Determining cellular CTCF and cohesin abundances to constrain 3D genome models

Achieving a quantitative and predictive understanding of 3D genome architecture remains a major challenge, as it requires quantitative measurements of the key proteins involved. Here, we report the quantification of CTCF and cohesin, two causal regulators of topologically associating domains (TADs)...

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Bibliographic Details
Main Authors: Claudia Cattoglio, Iryna Pustova, Nike Walther, Jaclyn J Ho, Merle Hantsche-Grininger, Carla J Inouye, M Julius Hossain, Gina M Dailey, Jan Ellenberg, Xavier Darzacq, Robert Tjian, Anders S Hansen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
CTCF
cohesin
loop extrusion
TAD
genome organization
Rad21
Online Access:https://elifesciences.org/articles/40164

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