miRNAs and their putative roles in the development and progression of Parkinson’s disease
Small regulatory RNAs, such as miRNAs, are increasingly being recognized not only as regulators of developmental processes but contributors to pathological states. The number of miRNAs determined experimentally to be involved in Parkinson’s disease (PD) development and progression is small and incl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-01-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00315/full |
| _version_ | 1818540532189626368 |
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| author | Garry eWong Richard eNass |
| author_facet | Garry eWong Richard eNass |
| author_sort | Garry eWong |
| collection | DOAJ |
| description | Small regulatory RNAs, such as miRNAs, are increasingly being recognized not only as regulators of developmental processes but contributors to pathological states. The number of miRNAs determined experimentally to be involved in Parkinson’s disease (PD) development and progression is small and includes regulators of pathologic proteins, neurotrophic factors, and xenobiotic metabolizing enzymes. PD gene-association studies have also indicated miRNAs in the pathology. In this review, we present known miRNAs and their validated targets that contribute to PD development and progression. We also incorporate data mining methods to link additional miRNAs with non-experimentally validated targets and propose additional roles of miRNAs in neurodegenerative processes. Furthermore we present the potential contribution of next-generation-sequencing approaches to elucidate mechanisms and etiology of PD through discovery of novel miRNAs and other noncoding RNA classes. |
| first_indexed | 2024-12-11T21:56:36Z |
| format | Article |
| id | doaj.art-823c0094d2754f6aa558fce10026394d |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-11T21:56:36Z |
| publishDate | 2013-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-823c0094d2754f6aa558fce10026394d2022-12-22T00:49:16ZengFrontiers Media S.A.Frontiers in Genetics1664-80212013-01-01310.3389/fgene.2012.0031538835miRNAs and their putative roles in the development and progression of Parkinson’s diseaseGarry eWong0Richard eNass1AI Virtanen Institute, University of Eastern FinlandIndiana University School of MedicineSmall regulatory RNAs, such as miRNAs, are increasingly being recognized not only as regulators of developmental processes but contributors to pathological states. The number of miRNAs determined experimentally to be involved in Parkinson’s disease (PD) development and progression is small and includes regulators of pathologic proteins, neurotrophic factors, and xenobiotic metabolizing enzymes. PD gene-association studies have also indicated miRNAs in the pathology. In this review, we present known miRNAs and their validated targets that contribute to PD development and progression. We also incorporate data mining methods to link additional miRNAs with non-experimentally validated targets and propose additional roles of miRNAs in neurodegenerative processes. Furthermore we present the potential contribution of next-generation-sequencing approaches to elucidate mechanisms and etiology of PD through discovery of novel miRNAs and other noncoding RNA classes.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00315/fullalpha-SynucleinDopamineneurodegenerationC. elegansmiR-7 |
| spellingShingle | Garry eWong Richard eNass miRNAs and their putative roles in the development and progression of Parkinson’s disease Frontiers in Genetics alpha-Synuclein Dopamine neurodegeneration C. elegans miR-7 |
| title | miRNAs and their putative roles in the development and progression of Parkinson’s disease |
| title_full | miRNAs and their putative roles in the development and progression of Parkinson’s disease |
| title_fullStr | miRNAs and their putative roles in the development and progression of Parkinson’s disease |
| title_full_unstemmed | miRNAs and their putative roles in the development and progression of Parkinson’s disease |
| title_short | miRNAs and their putative roles in the development and progression of Parkinson’s disease |
| title_sort | mirnas and their putative roles in the development and progression of parkinson s disease |
| topic | alpha-Synuclein Dopamine neurodegeneration C. elegans miR-7 |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00315/full |
| work_keys_str_mv | AT garryewong mirnasandtheirputativerolesinthedevelopmentandprogressionofparkinsonsdisease AT richardenass mirnasandtheirputativerolesinthedevelopmentandprogressionofparkinsonsdisease |