Clinical and Paraclinical Survey of Hospitalised Cases of Mucormycosis in Two Centres in Ghaemshahr and Sari during 2011-2018
Background and purpose: Zygomycosis (mucormycosis) is a rare fungal infection with high morbidity and mortality. This study evaluated mucormycosis's clinical and paraclinical features in patients admitted to Buali Hospital in Sari & Razi Hospital in Ghaemshahr, Mazandaran Province, Iran. Ma...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-11-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-19932-en.pdf |
| _version_ | 1797429021937500160 |
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| author | Lotfollah Davoodi Amir Mohammad Eskandari Akbar Hoseinnejad Bahareh Moayed Ahmadi Iman Haghani |
| author_facet | Lotfollah Davoodi Amir Mohammad Eskandari Akbar Hoseinnejad Bahareh Moayed Ahmadi Iman Haghani |
| author_sort | Lotfollah Davoodi |
| collection | DOAJ |
| description | Background and purpose: Zygomycosis (mucormycosis) is a rare fungal infection with high morbidity and mortality. This study evaluated mucormycosis's clinical and paraclinical features in patients admitted to Buali Hospital in Sari & Razi Hospital in Ghaemshahr, Mazandaran Province, Iran.
Materials and methods: This retrospective and cross-sectional study reviewed the patients' files with proven or probable mucormycosis admitted to Buali & Razi hospitals from 20 April 2011 to 20 April 2018. The Student's T-test and Fisher's exact test were performed for data analysis using SPSS version 27 software. P ≤ 0.05 was considered as a significant value.
Results: Out of 33 patients studied, 18 (54.55%) were female and 15 (45.45%) were male. The average age of the patients was 48.84 years. Among the signs and symptoms of the disease, most cases were related to headache. Diabetes was the most common underlying disease in these patients 28 (93.3%). The mortality rate in these patients was 48.48%, of which 25% related to mucormycosis. The genus Mucor and Rhizopus were the most common agents isolated in 9 cases of positive cultures.
Conclusion: Results indicate that people with diabetes are more susceptible to mucormycosis than others, and that control and reduction of diabetes in the community can significantly reduce the incidence of mucormycosis. surgery combined with timely medical treatment also has the highest survival rate. |
| first_indexed | 2024-03-09T09:07:11Z |
| format | Article |
| id | doaj.art-823eb90fc715474a8450c104d84ce367 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-09T09:07:11Z |
| publishDate | 2023-11-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-823eb90fc715474a8450c104d84ce3672023-12-02T10:14:03ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-11-0133227180191Clinical and Paraclinical Survey of Hospitalised Cases of Mucormycosis in Two Centres in Ghaemshahr and Sari during 2011-2018Lotfollah Davoodi0Amir Mohammad Eskandari1Akbar Hoseinnejad2Bahareh Moayed Ahmadi3Iman Haghani4 Assistant Professor, Department of Infectious Diseases, Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Sari, Iran Medical Student, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran General Practitioner, Sari Health Center, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran Assistant Professor, Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran and Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran Background and purpose: Zygomycosis (mucormycosis) is a rare fungal infection with high morbidity and mortality. This study evaluated mucormycosis's clinical and paraclinical features in patients admitted to Buali Hospital in Sari & Razi Hospital in Ghaemshahr, Mazandaran Province, Iran. Materials and methods: This retrospective and cross-sectional study reviewed the patients' files with proven or probable mucormycosis admitted to Buali & Razi hospitals from 20 April 2011 to 20 April 2018. The Student's T-test and Fisher's exact test were performed for data analysis using SPSS version 27 software. P ≤ 0.05 was considered as a significant value. Results: Out of 33 patients studied, 18 (54.55%) were female and 15 (45.45%) were male. The average age of the patients was 48.84 years. Among the signs and symptoms of the disease, most cases were related to headache. Diabetes was the most common underlying disease in these patients 28 (93.3%). The mortality rate in these patients was 48.48%, of which 25% related to mucormycosis. The genus Mucor and Rhizopus were the most common agents isolated in 9 cases of positive cultures. Conclusion: Results indicate that people with diabetes are more susceptible to mucormycosis than others, and that control and reduction of diabetes in the community can significantly reduce the incidence of mucormycosis. surgery combined with timely medical treatment also has the highest survival rate.http://jmums.mazums.ac.ir/article-1-19932-en.pdfamphotericin bdiabetesmucormycosis |
| spellingShingle | Lotfollah Davoodi Amir Mohammad Eskandari Akbar Hoseinnejad Bahareh Moayed Ahmadi Iman Haghani Clinical and Paraclinical Survey of Hospitalised Cases of Mucormycosis in Two Centres in Ghaemshahr and Sari during 2011-2018 Journal of Mazandaran University of Medical Sciences amphotericin b diabetes mucormycosis |
| title | Clinical and Paraclinical Survey of Hospitalised Cases of Mucormycosis in Two Centres in Ghaemshahr and Sari during 2011-2018 |
| title_full | Clinical and Paraclinical Survey of Hospitalised Cases of Mucormycosis in Two Centres in Ghaemshahr and Sari during 2011-2018 |
| title_fullStr | Clinical and Paraclinical Survey of Hospitalised Cases of Mucormycosis in Two Centres in Ghaemshahr and Sari during 2011-2018 |
| title_full_unstemmed | Clinical and Paraclinical Survey of Hospitalised Cases of Mucormycosis in Two Centres in Ghaemshahr and Sari during 2011-2018 |
| title_short | Clinical and Paraclinical Survey of Hospitalised Cases of Mucormycosis in Two Centres in Ghaemshahr and Sari during 2011-2018 |
| title_sort | clinical and paraclinical survey of hospitalised cases of mucormycosis in two centres in ghaemshahr and sari during 2011 2018 |
| topic | amphotericin b diabetes mucormycosis |
| url | http://jmums.mazums.ac.ir/article-1-19932-en.pdf |
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