Reduced pain sensitivity of episodic pain syndrome model mice carrying a Nav1.9 mutation by ANP-230, a novel sodium channel blocker

Reduced pain sensitivity of episodic pain syndrome model mice carrying a Nav1.9 mutation by ANP-230, a novel sodium channel blocker

The sodium channel Nav1.9 is expressed in the sensory neurons of small diameter dorsal root ganglia that transmit pain signals, and gain-of-function Nav1.9 mutations have been associated with both painful and painless disorders. We initially determined that some Nav1.9 mutations are responsible for...

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Bibliographic Details
Main Authors: Hiroko Okuda, Sumiko Inoue, Yoshihiro Oyamada, Akio Koizumi, Shohab Youssefian
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Heliyon
Subjects:
Episodic pain syndrome
Pain model mice
Sodium channel blocker
Nav1.9 voltage-gated sodium channel
Behavioral experiments
Electrophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023026300

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http://www.sciencedirect.com/science/article/pii/S2405844023026300

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